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Compound
PGDB_C016396
8 activity records2 related patents
2D structure
CC(C)(C(=O)NCc1cc(Cl)c(C2CCC(=O)NC2=O)c(Cl)c1)c1ccnc(F)c1Compound summary
Physicochemical properties
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IC50 | - | = | 0.0009 | uM | - | — | - | - | monocyte-derived macrophages | WO2025024521A1 | PGDB_A019884 | PGDB_C016396 | PGDB_AS000832 | View |
| DC50 | - | <= | 100 | nM | - | — | - | - | CAL-51 | KR20260041885A | PGDB_A040794 | PGDB_C016396 | PGDB_AS002572 | View |
| DC50 | - | < | 100 | nM | - | — | NEK7 | CRBN | - | WO2025024521A1 | PGDB_A045164 | PGDB_C016396 | PGDB_AS000280 | View |
| EC50 | - | < | 100 | nM | - | — | CRBN | CRBN | - | WO2025024521A1 | PGDB_A051578 | PGDB_C016396 | PGDB_AS000488 | View |
| Dmax | - | > | 75 | % | Concentration series: 1 uM, 0.05 nM | 24 h | - | - | CAL-51 | KR20260041885A | PGDB_A054001 | PGDB_C016396 | PGDB_AS001446 | View |
| IC50 | - | = | 0.00045 | uM | - | — | - | - | monocyte-derived macrophages | WO2025024521A1 | PGDB_A056633 | PGDB_C016396 | PGDB_AS001704 | View |
| EC50 | - | <= | 100 | nM | - | — | - | - | - | KR20260041885A | PGDB_A072503 | PGDB_C016396 | PGDB_AS001290 | View |
| Dmax | - | > | 75 | % | - | - | NEK7 | CRBN | - | WO2025024521A1 | PGDB_A075831 | PGDB_C016396 | PGDB_AS002165 | View |