PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(CN4CCN(c5cnnc(Cl)c5Cl)CC4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C019246

FormulaC22H22Cl2N6O3

Molecular weight489.363

InChIKeyHBSXBSAUQCFDGW-UHFFFAOYSA-N

Physicochemical properties

Exact mass488.113

RDKit cLogP1.87

TPSA98.7

HBD / HBA1 / 7

Rotatable bonds4

Heavy atoms33

Hetero atoms11

Rings / aromatic5 / 2

Fraction Csp30.41

Formal charge0

Fragments1

Activity compounds and values

Activity records

8 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
IC50	-	=	0.5-1	uM	-	—	CRBN	CRBN	-	WO2025016359A1	PGDB_A011946	PGDB_C019246	PGDB_AS001897	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2025016359A1	PGDB_A012716	PGDB_C019246	PGDB_AS000700	View
IC50	-	=	100-500	nM	-	—	IKZF3	-	CAL-62	WO2025016359A1	PGDB_A017800	PGDB_C019246	PGDB_AS000262	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025016359A1	PGDB_A019323	PGDB_C019246	PGDB_AS002465	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2025016359A1	PGDB_A026824	PGDB_C019246	PGDB_AS002547	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025016359A1	PGDB_A033142	PGDB_C019246	PGDB_AS001647	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025016359A1	PGDB_A052125	PGDB_C019246	PGDB_AS000593	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2025016359A1	PGDB_A063922	PGDB_C019246	PGDB_AS001760	View

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