PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(CN4CCC(c5cccs5)CC4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C019263

FormulaC23H25N3O3S

Molecular weight423.538

InChIKeyXEFUGPDSPZZNIB-UHFFFAOYSA-N

Physicochemical properties

Exact mass423.1617

RDKit cLogP2.89

TPSA69.7

HBD / HBA1 / 5

Rotatable bonds4

Heavy atoms30

Hetero atoms7

Rings / aromatic5 / 2

Fraction Csp30.43

Formal charge0

Fragments1

Activity compounds and values

Activity records

11 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2025016359A1	PGDB_A007595	PGDB_C019263	PGDB_AS002547	View
IC50	-	=	1-5	nM	-	—	IKZF3	-	MOLT-4	WO2025016359A1	PGDB_A009863	PGDB_C019263	PGDB_AS001975	View
IC50	-	=	10-50	nM	-	—	IKZF3	-	H1975	WO2025016359A1	PGDB_A026209	PGDB_C019263	PGDB_AS000939	View
IC50	-	=	10-50	nM	-	—	IKZF3	-	TMD8	WO2025016359A1	PGDB_A040705	PGDB_C019263	PGDB_AS000926	View
IC50	-	=	10-50	nM	-	—	IKZF3	-	MDA-MB-231	WO2025016359A1	PGDB_A041073	PGDB_C019263	PGDB_AS000537	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2025016359A1	PGDB_A050175	PGDB_C019263	PGDB_AS000700	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2025016359A1	PGDB_A051720	PGDB_C019263	PGDB_AS001760	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025016359A1	PGDB_A056324	PGDB_C019263	PGDB_AS000593	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025016359A1	PGDB_A068392	PGDB_C019263	PGDB_AS002465	View
IC50	-	=	1-1.5	uM	-	—	CRBN	CRBN	-	WO2025016359A1	PGDB_A072431	PGDB_C019263	PGDB_AS001897	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025016359A1	PGDB_A076280	PGDB_C019263	PGDB_AS001647	View

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