PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

Cc1cc(C2CCN(Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)cs1

Compound summary

Compound IDPGDB_C019274

FormulaC24H27N3O3S

Molecular weight437.565

InChIKeyFJGKFJIXOULVFZ-UHFFFAOYSA-N

Physicochemical properties

Exact mass437.1773

RDKit cLogP3.2

TPSA69.7

HBD / HBA1 / 5

Rotatable bonds4

Heavy atoms31

Hetero atoms7

Rings / aromatic5 / 2

Fraction Csp30.46

Formal charge0

Fragments1

Activity compounds and values

Activity records

11 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025016359A1	PGDB_A014427	PGDB_C019274	PGDB_AS002465	View
IC50	-	=	1-1.5	uM	-	—	CRBN	CRBN	-	WO2025016359A1	PGDB_A016358	PGDB_C019274	PGDB_AS001897	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025016359A1	PGDB_A022805	PGDB_C019274	PGDB_AS001647	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2025016359A1	PGDB_A029531	PGDB_C019274	PGDB_AS002547	View
IC50	-	=	500-1000	nM	-	—	IKZF3	-	TMD8	WO2025016359A1	PGDB_A034907	PGDB_C019274	PGDB_AS000926	View
IC50	-	=	10-50	nM	-	—	IKZF3	-	MOLT-4	WO2025016359A1	PGDB_A037081	PGDB_C019274	PGDB_AS001975	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025016359A1	PGDB_A038867	PGDB_C019274	PGDB_AS000593	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2025016359A1	PGDB_A040082	PGDB_C019274	PGDB_AS001760	View
IC50	-	=	100-500	nM	-	—	IKZF3	-	H1975	WO2025016359A1	PGDB_A045166	PGDB_C019274	PGDB_AS000939	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2025016359A1	PGDB_A065534	PGDB_C019274	PGDB_AS000700	View
IC50	-	=	100-500	nM	-	—	IKZF3	-	MDA-MB-231	WO2025016359A1	PGDB_A073215	PGDB_C019274	PGDB_AS000537	View

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