PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(CN4CC=C(c5ccoc5)CC4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C019275

FormulaC23H23N3O4

Molecular weight405.454

InChIKeyVRGXHIJAMVZCCA-UHFFFAOYSA-N

Physicochemical properties

Exact mass405.1689

RDKit cLogP2.33

TPSA82.9

HBD / HBA1 / 5

Rotatable bonds4

Heavy atoms30

Hetero atoms7

Rings / aromatic5 / 2

Fraction Csp30.35

Formal charge0

Fragments1

Activity compounds and values

Activity records

10 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
IC50	-	=	500-1000	nM	-	—	IKZF3	-	MDA-MB-231	WO2025016359A1	PGDB_A013281	PGDB_C019275	PGDB_AS000537	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025016359A1	PGDB_A016001	PGDB_C019275	PGDB_AS000593	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2025016359A1	PGDB_A016784	PGDB_C019275	PGDB_AS002547	View
IC50	-	=	500-1000	nM	-	—	IKZF3	-	TMD8	WO2025016359A1	PGDB_A017351	PGDB_C019275	PGDB_AS000926	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2025016359A1	PGDB_A034843	PGDB_C019275	PGDB_AS001760	View
IC50	-	<=	0.5	uM	-	—	CRBN	CRBN	-	WO2025016359A1	PGDB_A039665	PGDB_C019275	PGDB_AS001897	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2025016359A1	PGDB_A052863	PGDB_C019275	PGDB_AS000700	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025016359A1	PGDB_A056983	PGDB_C019275	PGDB_AS001647	View
IC50	-	=	100-500	nM	-	—	IKZF3	-	MOLT-4	WO2025016359A1	PGDB_A061115	PGDB_C019275	PGDB_AS001975	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025016359A1	PGDB_A072040	PGDB_C019275	PGDB_AS002465	View

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