PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(CN4CCN(c5nccc(Cl)c5F)CC4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C019282

FormulaC23H23ClFN5O3

Molecular weight471.92

InChIKeyZRIWCBYELHFOEW-UHFFFAOYSA-N

Physicochemical properties

Exact mass471.1473

RDKit cLogP1.96

TPSA85.8

HBD / HBA1 / 6

Rotatable bonds4

Heavy atoms33

Hetero atoms10

Rings / aromatic5 / 2

Fraction Csp30.39

Formal charge0

Fragments1

Activity compounds and values

Activity records

11 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025016359A1	PGDB_A012447	PGDB_C019282	PGDB_AS002465	View
IC50	-	=	10-50	nM	-	—	IKZF3	-	MDA-MB-231	WO2025016359A1	PGDB_A015295	PGDB_C019282	PGDB_AS000537	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2025016359A1	PGDB_A019696	PGDB_C019282	PGDB_AS001760	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2025016359A1	PGDB_A023602	PGDB_C019282	PGDB_AS002547	View
IC50	-	=	0.5-1	uM	-	—	CRBN	CRBN	-	WO2025016359A1	PGDB_A029843	PGDB_C019282	PGDB_AS001897	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2025016359A1	PGDB_A039497	PGDB_C019282	PGDB_AS000700	View
IC50	-	=	10-50	nM	-	—	IKZF3	-	H1975	WO2025016359A1	PGDB_A044576	PGDB_C019282	PGDB_AS000939	View
IC50	-	=	1-5	nM	-	—	IKZF3	-	MOLT-4	WO2025016359A1	PGDB_A046578	PGDB_C019282	PGDB_AS001975	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025016359A1	PGDB_A048337	PGDB_C019282	PGDB_AS001647	View
IC50	-	=	10-50	nM	-	—	IKZF3	-	TMD8	WO2025016359A1	PGDB_A051450	PGDB_C019282	PGDB_AS000926	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025016359A1	PGDB_A074303	PGDB_C019282	PGDB_AS000593	View

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