PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(CN4CCC(c5cccc6c(F)cccc56)CC4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C019296

FormulaC29H28FN3O3

Molecular weight485.559

InChIKeyIDSOTWACXBIXML-UHFFFAOYSA-N

Physicochemical properties

Exact mass485.2115

RDKit cLogP4.12

TPSA69.7

HBD / HBA1 / 4

Rotatable bonds4

Heavy atoms36

Hetero atoms7

Rings / aromatic6 / 3

Fraction Csp30.34

Formal charge0

Fragments1

Activity compounds and values

Activity records

11 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
IC50	-	=	5-10	nM	-	—	IKZF3	-	MDA-MB-231	WO2025016359A1	PGDB_A018104	PGDB_C019296	PGDB_AS000537	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2025016359A1	PGDB_A019974	PGDB_C019296	PGDB_AS001760	View
IC50	-	=	0.5-1	uM	-	—	CRBN	CRBN	-	WO2025016359A1	PGDB_A024781	PGDB_C019296	PGDB_AS001897	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025016359A1	PGDB_A025929	PGDB_C019296	PGDB_AS002465	View
IC50	-	=	10-50	nM	-	—	IKZF3	-	TMD8	WO2025016359A1	PGDB_A036921	PGDB_C019296	PGDB_AS000926	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2025016359A1	PGDB_A046896	PGDB_C019296	PGDB_AS000700	View
IC50	-	=	10-50	nM	-	—	IKZF3	-	H1975	WO2025016359A1	PGDB_A060983	PGDB_C019296	PGDB_AS000939	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025016359A1	PGDB_A065490	PGDB_C019296	PGDB_AS001647	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025016359A1	PGDB_A072086	PGDB_C019296	PGDB_AS000593	View
IC50	-	=	1-5	nM	-	—	IKZF3	-	MOLT-4	WO2025016359A1	PGDB_A072145	PGDB_C019296	PGDB_AS001975	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2025016359A1	PGDB_A076878	PGDB_C019296	PGDB_AS002547	View

Rows per pagePage 1 of 1 · 11 recordsGo to page