PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(CN4CC(N5CCc6cc(F)ccc65)C4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C019300

FormulaC25H25FN4O3

Molecular weight448.498

InChIKeySJLATAYYHTVZLX-UHFFFAOYSA-N

Physicochemical properties

Exact mass448.1911

RDKit cLogP1.83

TPSA73

HBD / HBA1 / 5

Rotatable bonds4

Heavy atoms33

Hetero atoms8

Rings / aromatic6 / 2

Fraction Csp30.4

Formal charge0

Fragments1

Activity compounds and values

Activity records

11 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025016359A1	PGDB_A007992	PGDB_C019300	PGDB_AS001647	View
IC50	-	=	10-50	nM	-	—	IKZF3	-	MDA-MB-231	WO2025016359A1	PGDB_A011620	PGDB_C019300	PGDB_AS000537	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2025016359A1	PGDB_A024892	PGDB_C019300	PGDB_AS001760	View
IC50	-	=	50-100	nM	-	—	IKZF3	-	H1975	WO2025016359A1	PGDB_A028342	PGDB_C019300	PGDB_AS000939	View
IC50	-	<=	0.5	uM	-	—	CRBN	CRBN	-	WO2025016359A1	PGDB_A048357	PGDB_C019300	PGDB_AS001897	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2025016359A1	PGDB_A055336	PGDB_C019300	PGDB_AS000700	View
IC50	-	=	5-10	nM	-	—	IKZF3	-	MOLT-4	WO2025016359A1	PGDB_A057384	PGDB_C019300	PGDB_AS001975	View
IC50	-	=	50-100	nM	-	—	IKZF3	-	TMD8	WO2025016359A1	PGDB_A065936	PGDB_C019300	PGDB_AS000926	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2025016359A1	PGDB_A072065	PGDB_C019300	PGDB_AS002547	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025016359A1	PGDB_A075264	PGDB_C019300	PGDB_AS002465	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025016359A1	PGDB_A076806	PGDB_C019300	PGDB_AS000593	View

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