PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(CN4CC=C(c5ncnc6sccc56)CC4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C019308

FormulaC25H23N5O3S

Molecular weight473.558

InChIKeyAKLPDNVUKKLHFR-UHFFFAOYSA-N

Physicochemical properties

Exact mass473.1522

RDKit cLogP2.74

TPSA95.5

HBD / HBA1 / 7

Rotatable bonds4

Heavy atoms34

Hetero atoms9

Rings / aromatic6 / 3

Fraction Csp30.32

Formal charge0

Fragments1

Activity compounds and values

Activity records

11 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
IC50	-	=	10-50	nM	-	—	IKZF3	-	MDA-MB-231	WO2025016359A1	PGDB_A009335	PGDB_C019308	PGDB_AS000537	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2025016359A1	PGDB_A010830	PGDB_C019308	PGDB_AS000700	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025016359A1	PGDB_A025774	PGDB_C019308	PGDB_AS001647	View
IC50	-	=	1-5	nM	-	—	IKZF3	-	MOLT-4	WO2025016359A1	PGDB_A029015	PGDB_C019308	PGDB_AS001975	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2025016359A1	PGDB_A034522	PGDB_C019308	PGDB_AS002547	View
IC50	-	=	50-100	nM	-	—	IKZF3	-	TMD8	WO2025016359A1	PGDB_A045591	PGDB_C019308	PGDB_AS000926	View
IC50	-	<=	0.5	uM	-	—	CRBN	CRBN	-	WO2025016359A1	PGDB_A062287	PGDB_C019308	PGDB_AS001897	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2025016359A1	PGDB_A064601	PGDB_C019308	PGDB_AS001760	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025016359A1	PGDB_A067007	PGDB_C019308	PGDB_AS000593	View
IC50	-	=	50-100	nM	-	—	IKZF3	-	H1975	WO2025016359A1	PGDB_A074918	PGDB_C019308	PGDB_AS000939	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025016359A1	PGDB_A076333	PGDB_C019308	PGDB_AS002465	View

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