PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

Cc1csc2ncnc(C3=CCN(Cc4ccc5c(c4)CN(C4CCC(=O)NC4=O)C5=O)CC3)c12

Compound summary

Compound IDPGDB_C019315

FormulaC26H25N5O3S

Molecular weight487.585

InChIKeyDWRWAHBWQOMOBI-UHFFFAOYSA-N

Physicochemical properties

Exact mass487.1678

RDKit cLogP3.05

TPSA95.5

HBD / HBA1 / 7

Rotatable bonds4

Heavy atoms35

Hetero atoms9

Rings / aromatic6 / 3

Fraction Csp30.35

Formal charge0

Fragments1

Activity compounds and values

Activity records

11 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
IC50	-	=	10-50	nM	-	—	IKZF3	-	MDA-MB-231	WO2025016359A1	PGDB_A017451	PGDB_C019315	PGDB_AS000537	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025016359A1	PGDB_A024655	PGDB_C019315	PGDB_AS002465	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025016359A1	PGDB_A025054	PGDB_C019315	PGDB_AS001647	View
IC50	-	=	10-50	nM	-	—	IKZF3	-	TMD8	WO2025016359A1	PGDB_A027077	PGDB_C019315	PGDB_AS000926	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025016359A1	PGDB_A035831	PGDB_C019315	PGDB_AS000593	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2025016359A1	PGDB_A039554	PGDB_C019315	PGDB_AS002547	View
IC50	-	=	1-5	nM	-	—	IKZF3	-	MOLT-4	WO2025016359A1	PGDB_A047993	PGDB_C019315	PGDB_AS001975	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2025016359A1	PGDB_A059952	PGDB_C019315	PGDB_AS000700	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2025016359A1	PGDB_A060611	PGDB_C019315	PGDB_AS001760	View
IC50	-	=	10-50	nM	-	—	IKZF3	-	H1975	WO2025016359A1	PGDB_A065782	PGDB_C019315	PGDB_AS000939	View
IC50	-	=	0.5-1	uM	-	—	CRBN	CRBN	-	WO2025016359A1	PGDB_A071599	PGDB_C019315	PGDB_AS001897	View

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