PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(CN4C5CC4CN(c4cccc(Cl)c4Cl)C5)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C019323

FormulaC25H24Cl2N4O3

Molecular weight499.398

InChIKeyNRPAMCKUUGBRPL-UHFFFAOYSA-N

Physicochemical properties

Exact mass498.1225

RDKit cLogP3.22

TPSA73

HBD / HBA1 / 5

Rotatable bonds4

Heavy atoms34

Hetero atoms9

Rings / aromatic7 / 2

Fraction Csp30.4

Formal charge0

Fragments1

Activity compounds and values

Activity records

11 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025016359A1	PGDB_A031864	PGDB_C019323	PGDB_AS001647	View
IC50	-	=	10-50	nM	-	—	IKZF3	-	TMD8	WO2025016359A1	PGDB_A032318	PGDB_C019323	PGDB_AS000926	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025016359A1	PGDB_A032681	PGDB_C019323	PGDB_AS002465	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2025016359A1	PGDB_A034836	PGDB_C019323	PGDB_AS002547	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2025016359A1	PGDB_A041176	PGDB_C019323	PGDB_AS001760	View
IC50	-	=	1-5	nM	-	—	IKZF3	-	MOLT-4	WO2025016359A1	PGDB_A041674	PGDB_C019323	PGDB_AS001975	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025016359A1	PGDB_A044119	PGDB_C019323	PGDB_AS000593	View
IC50	-	=	5-10	nM	-	—	IKZF3	-	H1975	WO2025016359A1	PGDB_A047658	PGDB_C019323	PGDB_AS000939	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2025016359A1	PGDB_A058423	PGDB_C019323	PGDB_AS000700	View
IC50	-	=	0.5-1	uM	-	—	CRBN	CRBN	-	WO2025016359A1	PGDB_A064682	PGDB_C019323	PGDB_AS001897	View
IC50	-	=	1-5	nM	-	—	IKZF3	-	MDA-MB-231	WO2025016359A1	PGDB_A065503	PGDB_C019323	PGDB_AS000537	View

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