PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(CN4CC=C(c5c[nH]c6cc(F)ccc56)CC4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C019330

FormulaC27H25FN4O3

Molecular weight472.52

InChIKeyGNTCNPJOROPYFJ-UHFFFAOYSA-N

Physicochemical properties

Exact mass472.1911

RDKit cLogP3.36

TPSA85.5

HBD / HBA2 / 4

Rotatable bonds4

Heavy atoms35

Hetero atoms8

Rings / aromatic6 / 3

Fraction Csp30.3

Formal charge0

Fragments1

Activity compounds and values

Activity records

11 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025016359A1	PGDB_A012328	PGDB_C019330	PGDB_AS001647	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2025016359A1	PGDB_A014410	PGDB_C019330	PGDB_AS000700	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025016359A1	PGDB_A015857	PGDB_C019330	PGDB_AS000593	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2025016359A1	PGDB_A019813	PGDB_C019330	PGDB_AS001760	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2025016359A1	PGDB_A022495	PGDB_C019330	PGDB_AS002547	View
IC50	-	=	10-50	nM	-	—	IKZF3	-	H1975	WO2025016359A1	PGDB_A025629	PGDB_C019330	PGDB_AS000939	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025016359A1	PGDB_A033705	PGDB_C019330	PGDB_AS002465	View
IC50	-	=	10-50	nM	-	—	IKZF3	-	TMD8	WO2025016359A1	PGDB_A036254	PGDB_C019330	PGDB_AS000926	View
IC50	-	=	1-5	nM	-	—	IKZF3	-	MOLT-4	WO2025016359A1	PGDB_A055510	PGDB_C019330	PGDB_AS001975	View
IC50	-	<=	0.5	uM	-	—	CRBN	CRBN	-	WO2025016359A1	PGDB_A065988	PGDB_C019330	PGDB_AS001897	View
IC50	-	=	5-10	nM	-	—	IKZF3	-	MDA-MB-231	WO2025016359A1	PGDB_A071964	PGDB_C019330	PGDB_AS000537	View

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