PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

Cn1cc(C2=CCN(Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)c2ccc(F)cc21

Compound summary

Compound IDPGDB_C019331

FormulaC28H27FN4O3

Molecular weight486.547

InChIKeyDFUKUZAZTNWJQS-UHFFFAOYSA-N

Physicochemical properties

Exact mass486.2067

RDKit cLogP3.37

TPSA74.7

HBD / HBA1 / 5

Rotatable bonds4

Heavy atoms36

Hetero atoms8

Rings / aromatic6 / 3

Fraction Csp30.32

Formal charge0

Fragments1

Activity compounds and values

Activity records

11 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
IC50	-	=	50-100	nM	-	—	IKZF3	-	TMD8	WO2025016359A1	PGDB_A007109	PGDB_C019331	PGDB_AS000926	View
IC50	-	<=	0.5	uM	-	—	CRBN	CRBN	-	WO2025016359A1	PGDB_A009040	PGDB_C019331	PGDB_AS001897	View
IC50	-	=	50-100	nM	-	—	IKZF3	-	H1975	WO2025016359A1	PGDB_A018303	PGDB_C019331	PGDB_AS000939	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2025016359A1	PGDB_A023248	PGDB_C019331	PGDB_AS002547	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025016359A1	PGDB_A026409	PGDB_C019331	PGDB_AS001647	View
IC50	-	=	5-10	nM	-	—	IKZF3	-	MOLT-4	WO2025016359A1	PGDB_A032671	PGDB_C019331	PGDB_AS001975	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2025016359A1	PGDB_A043455	PGDB_C019331	PGDB_AS000700	View
IC50	-	=	10-50	nM	-	—	IKZF3	-	MDA-MB-231	WO2025016359A1	PGDB_A048217	PGDB_C019331	PGDB_AS000537	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025016359A1	PGDB_A059189	PGDB_C019331	PGDB_AS002465	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2025016359A1	PGDB_A066683	PGDB_C019331	PGDB_AS001760	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025016359A1	PGDB_A067955	PGDB_C019331	PGDB_AS000593	View

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