PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3c(ccc(CN4CCC(c5noc6cc(F)ccc56)CC4)c3F)C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C019340

FormulaC26H24F2N4O4

Molecular weight494.498

InChIKeyYNMGZOIQFHYBSS-UHFFFAOYSA-N

Physicochemical properties

Exact mass494.1766

RDKit cLogP3.25

TPSA95.8

HBD / HBA1 / 6

Rotatable bonds4

Heavy atoms36

Hetero atoms10

Rings / aromatic6 / 3

Fraction Csp30.38

Formal charge0

Fragments1

Activity compounds and values

Activity records

11 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025016359A1	PGDB_A009380	PGDB_C019340	PGDB_AS001647	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025016359A1	PGDB_A011169	PGDB_C019340	PGDB_AS000593	View
IC50	-	=	5-10	nM	-	—	IKZF3	-	MOLT-4	WO2025016359A1	PGDB_A013980	PGDB_C019340	PGDB_AS001975	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2025016359A1	PGDB_A016097	PGDB_C019340	PGDB_AS002547	View
IC50	-	=	50-100	nM	-	—	IKZF3	-	H1975	WO2025016359A1	PGDB_A031838	PGDB_C019340	PGDB_AS000939	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2025016359A1	PGDB_A033505	PGDB_C019340	PGDB_AS000700	View
IC50	-	=	100-500	nM	-	—	IKZF3	-	TMD8	WO2025016359A1	PGDB_A043353	PGDB_C019340	PGDB_AS000926	View
IC50	-	=	1-1.5	uM	-	—	CRBN	CRBN	-	WO2025016359A1	PGDB_A050580	PGDB_C019340	PGDB_AS001897	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025016359A1	PGDB_A056944	PGDB_C019340	PGDB_AS002465	View
IC50	-	=	10-50	nM	-	—	IKZF3	-	MDA-MB-231	WO2025016359A1	PGDB_A064055	PGDB_C019340	PGDB_AS000537	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2025016359A1	PGDB_A070893	PGDB_C019340	PGDB_AS001760	View

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