PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(CN4CC=C(c5ncnc6sc7c(c56)CCC7)CC4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C019363

FormulaC28H27N5O3S

Molecular weight513.623

InChIKeyXZBNWFZZRYVUFA-UHFFFAOYSA-N

Physicochemical properties

Exact mass513.1835

RDKit cLogP3.23

TPSA95.5

HBD / HBA1 / 7

Rotatable bonds4

Heavy atoms37

Hetero atoms9

Rings / aromatic7 / 3

Fraction Csp30.39

Formal charge0

Fragments1

Activity compounds and values

Activity records

11 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
IC50	-	=	100-500	nM	-	—	-	-	SR	WO2025016359A1	PGDB_A007558	PGDB_C019363	PGDB_AS000403	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2025016359A1	PGDB_A016613	PGDB_C019363	PGDB_AS002547	View
IC50	-	<=	0.5	uM	-	—	CRBN	CRBN	-	WO2025016359A1	PGDB_A032300	PGDB_C019363	PGDB_AS001897	View
IC50	-	=	50-100	nM	-	—	-	-	H1975	WO2025016359A1	PGDB_A038302	PGDB_C019363	PGDB_AS000559	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2025016359A1	PGDB_A039821	PGDB_C019363	PGDB_AS000700	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025016359A1	PGDB_A040053	PGDB_C019363	PGDB_AS002465	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025016359A1	PGDB_A051645	PGDB_C019363	PGDB_AS000593	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2025016359A1	PGDB_A054144	PGDB_C019363	PGDB_AS001760	View
IC50	-	=	10-50	nM	-	—	-	-	Jurkat	WO2025016359A1	PGDB_A058435	PGDB_C019363	PGDB_AS002351	View
IC50	-	<=	1	nM	-	—	-	-	MM.1S	WO2025016359A1	PGDB_A062539	PGDB_C019363	PGDB_AS001138	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025016359A1	PGDB_A064246	PGDB_C019363	PGDB_AS001647	View

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