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Compound
PGDB_C020387
8 activity records2 related patents
2D structure
CC(C)(C(=O)NCc1cc(Cl)c(C2CCC(=O)NC2=O)c(Cl)c1)c1ccc(CC#N)nn1Compound summary
Physicochemical properties
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| DC50 | - | = | 100-1000 | nM | - | — | NEK7 | CRBN | - | WO2025024521A1 | PGDB_A007257 | PGDB_C020387 | PGDB_AS000280 | View |
| Dmax | - | < | 50 | % | - | - | NEK7 | CRBN | - | WO2025024521A1 | PGDB_A022679 | PGDB_C020387 | PGDB_AS002165 | View |
| Dmax | - | = | 49 | % | Concentration series: 1 uM, 0.05 nM | 24 h | NEK7 | - | CAL-51 | WO2025024521A1 | PGDB_A024322 | PGDB_C020387 | PGDB_AS002061 | View |
| DC50 | - | = | 635 | nM | - | — | NEK7 | - | CAL-51 | WO2025024521A1 | PGDB_A042493 | PGDB_C020387 | PGDB_AS001365 | View |
| Dmax | - | <= | 50 | % | Concentration context: various concentrations | 24 h | - | - | CAL-51 | KR20260041885A | PGDB_A052367 | PGDB_C020387 | PGDB_AS000078 | View |
| Dmax | - | = | 50-75 | % | - | - | NEK7 | CRBN | - | WO2025024521A1 | PGDB_A059464 | PGDB_C020387 | PGDB_AS002165 | View |
| EC50 | - | = | 100-1000 | nM | - | — | CRBN | CRBN | - | WO2025024521A1 | PGDB_A062129 | PGDB_C020387 | PGDB_AS000488 | View |
| DC50 | - | = | 100-1000 | nM | - | — | NEK7 | CRBN | - | WO2025024521A1 | PGDB_A072906 | PGDB_C020387 | PGDB_AS000280 | View |