PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(NN4CCN(C(=O)c5ccccc5-c5ccc(Cl)cc5)CC4)cc(F)c3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C024193

FormulaC30H27ClFN5O4

Molecular weight576.028

InChIKeyGZTRYYODUSPDRH-UHFFFAOYSA-N

Physicochemical properties

Exact mass575.1736

RDKit cLogP3.69

TPSA102.1

HBD / HBA2 / 6

Rotatable bonds5

Heavy atoms41

Hetero atoms11

Rings / aromatic6 / 3

Fraction Csp30.27

Formal charge0

Fragments1

Activity compounds and values

Activity records

15 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Inhibition	-	=	0-10	%	10 nM	96 h	IKZF3	-	H196	WO2025162225A1	PGDB_A018869	PGDB_C024193	PGDB_AS001140	View
% Inhibition	-	=	80-100	%	500 nM	96 h	IKZF3	-	CFPAC-1	WO2025162225A1	PGDB_A019332	PGDB_C024193	PGDB_AS000857	View
IC50	-	>	10	nM	-	—	-	-	TMD8	WO2025162225A1	PGDB_A021825	PGDB_C024193	PGDB_AS000863	View
% Inhibition	-	=	80-100	%	10 nM	96 h	IKZF3	-	CFPAC-1	WO2025162225A1	PGDB_A023415	PGDB_C024193	PGDB_AS000245	View
IC50	-	>	1	nM	-	—	-	-	MM.1S	WO2025162225A1	PGDB_A025576	PGDB_C024193	PGDB_AS001456	View
% Inhibition	-	=	70-80	%	500 nM	96 h	IKZF3	-	H196	WO2025162225A1	PGDB_A033573	PGDB_C024193	PGDB_AS000866	View
IC50	-	>	10	nM	-	—	-	-	RPMI-8226	WO2025162225A1	PGDB_A033824	PGDB_C024193	PGDB_AS000547	View
% Inhibition	-	=	50-60	%	500 nM	96 h	IKZF3	-	TMD8	WO2025162225A1	PGDB_A034813	PGDB_C024193	PGDB_AS002558	View
% Inhibition	-	=	10-20	%	10 nM	96 h	IKZF3	-	TMD8	WO2025162225A1	PGDB_A036862	PGDB_C024193	PGDB_AS000160	View
% Inhibition	-	=	80-100	%	500 nM	96 h	IKZF3	-	MV-4-11	WO2025162225A1	PGDB_A041081	PGDB_C024193	PGDB_AS001561	View
% Inhibition	-	=	80-100	%	500 nM	96 h	IKZF3	-	A375	WO2025162225A1	PGDB_A043308	PGDB_C024193	PGDB_AS000568	View
% Inhibition	-	=	80-100	%	500 nM	96 h	IKZF3	-	RPMI-8226	WO2025162225A1	PGDB_A050956	PGDB_C024193	PGDB_AS001812	View
% Inhibition	-	=	30-40	%	10 nM	96 h	IKZF3	-	RPMI-8226	WO2025162225A1	PGDB_A051230	PGDB_C024193	PGDB_AS000859	View
% Inhibition	-	=	30-40	%	10 nM	96 h	IKZF3	-	A375	WO2025162225A1	PGDB_A054279	PGDB_C024193	PGDB_AS001349	View
% Inhibition	-	=	30-40	%	10 nM	96 h	IKZF3	-	MV-4-11	WO2025162225A1	PGDB_A060683	PGDB_C024193	PGDB_AS001155	View

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