PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(NN4CCN(C(=O)c5ccccc5-c5ccc(Cl)cc5)CC4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C024194

FormulaC30H28ClN5O4

Molecular weight558.038

InChIKeyBLHXRBWUAVXRMT-UHFFFAOYSA-N

Physicochemical properties

Exact mass557.183

RDKit cLogP3.55

TPSA102.1

HBD / HBA2 / 6

Rotatable bonds5

Heavy atoms40

Hetero atoms10

Rings / aromatic6 / 3

Fraction Csp30.27

Formal charge0

Fragments1

Activity compounds and values

Activity records

14 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Inhibition	-	=	80-100	%	500 nM	96 h	IKZF3	-	RPMI-8226	WO2025162225A1	PGDB_A014249	PGDB_C024194	PGDB_AS001812	View
% Inhibition	-	=	30-40	%	10 nM	96 h	IKZF3	-	A375	WO2025162225A1	PGDB_A014669	PGDB_C024194	PGDB_AS001349	View
% Inhibition	-	=	80-100	%	500 nM	96 h	IKZF3	-	H196	WO2025162225A1	PGDB_A015339	PGDB_C024194	PGDB_AS000866	View
% Inhibition	-	=	80-100	%	500 nM	96 h	IKZF3	-	CFPAC-1	WO2025162225A1	PGDB_A033933	PGDB_C024194	PGDB_AS000857	View
IC50	-	>	10	nM	-	—	-	-	RPMI-8226	WO2025162225A1	PGDB_A034689	PGDB_C024194	PGDB_AS000547	View
% Inhibition	-	=	70-80	%	500 nM	96 h	IKZF3	-	TMD8	WO2025162225A1	PGDB_A042462	PGDB_C024194	PGDB_AS002558	View
% Inhibition	-	=	80-100	%	10 nM	96 h	IKZF3	-	CFPAC-1	WO2025162225A1	PGDB_A045467	PGDB_C024194	PGDB_AS000245	View
% Inhibition	-	=	0-10	%	10 nM	96 h	IKZF3	-	H196	WO2025162225A1	PGDB_A048275	PGDB_C024194	PGDB_AS001140	View
% Inhibition	-	=	80-100	%	500 nM	96 h	IKZF3	-	A375	WO2025162225A1	PGDB_A056127	PGDB_C024194	PGDB_AS000568	View
% Inhibition	-	=	80-100	%	500 nM	96 h	IKZF3	-	MV-4-11	WO2025162225A1	PGDB_A062069	PGDB_C024194	PGDB_AS001561	View
% Inhibition	-	=	20-30	%	10 nM	96 h	IKZF3	-	TMD8	WO2025162225A1	PGDB_A063849	PGDB_C024194	PGDB_AS000160	View
% Inhibition	-	=	50-60	%	10 nM	96 h	IKZF3	-	MV-4-11	WO2025162225A1	PGDB_A064149	PGDB_C024194	PGDB_AS001155	View
IC50	-	>	1	nM	-	—	-	-	MM.1S	WO2025162225A1	PGDB_A069248	PGDB_C024194	PGDB_AS001456	View
% Inhibition	-	=	30-40	%	10 nM	96 h	IKZF3	-	RPMI-8226	WO2025162225A1	PGDB_A074947	PGDB_C024194	PGDB_AS000859	View

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