PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3c(NN4CCN(C(c5ccc(Cl)cc5)c5ccc(Cl)cc5)CC4)cccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C024204

FormulaC30H29Cl2N5O3

Molecular weight578.5

InChIKeyWPIMCKPEQWVLNF-UHFFFAOYSA-N

Physicochemical properties

Exact mass577.1647

RDKit cLogP4.49

TPSA85

HBD / HBA2 / 6

Rotatable bonds6

Heavy atoms40

Hetero atoms10

Rings / aromatic6 / 3

Fraction Csp30.3

Formal charge0

Fragments1

Activity compounds and values

Activity records

12 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	CRBN	-	WO2025162225A1	PGDB_A030970	PGDB_C024204	PGDB_AS002453	View
% Inhibition	-	=	40-50	%	500 nM	96 h	IKZF3	-	A375	WO2025162225A1	PGDB_A035109	PGDB_C024204	PGDB_AS000568	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025162225A1	PGDB_A040656	PGDB_C024204	PGDB_AS000689	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025162225A1	PGDB_A043014	PGDB_C024204	PGDB_AS000351	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	CRBN	-	WO2025162225A1	PGDB_A044310	PGDB_C024204	PGDB_AS001726	View
% Inhibition	-	=	50-60	%	10 nM	96 h	IKZF3	-	H196	WO2025162225A1	PGDB_A046726	PGDB_C024204	PGDB_AS001140	View
% Inhibition	-	=	0-10	%	10 nM	96 h	IKZF3	-	CFPAC-1	WO2025162225A1	PGDB_A053688	PGDB_C024204	PGDB_AS000245	View
% Inhibition	-	=	40-50	%	500 nM	96 h	IKZF3	-	CFPAC-1	WO2025162225A1	PGDB_A056522	PGDB_C024204	PGDB_AS000857	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025162225A1	PGDB_A060119	PGDB_C024204	PGDB_AS000091	View
% Inhibition	-	=	50-60	%	500 nM	96 h	IKZF3	-	H196	WO2025162225A1	PGDB_A060598	PGDB_C024204	PGDB_AS000866	View
% Inhibition	-	=	0-10	%	10 nM	96 h	IKZF3	-	A375	WO2025162225A1	PGDB_A061191	PGDB_C024204	PGDB_AS001349	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	CRBN	-	WO2025162225A1	PGDB_A062059	PGDB_C024204	PGDB_AS000750	View

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