PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(NN4CC5CC4CN5C(c4cccc(F)c4)c4cccc(F)c4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C024248

FormulaC31H29F2N5O3

Molecular weight557.601

InChIKeyXLPSSNXKVDTQKD-UHFFFAOYSA-N

Physicochemical properties

Exact mass557.2238

RDKit cLogP3.6

TPSA85

HBD / HBA2 / 6

Rotatable bonds6

Heavy atoms41

Hetero atoms10

Rings / aromatic7 / 3

Fraction Csp30.32

Formal charge0

Fragments1

Activity compounds and values

Activity records

16 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	CRBN	-	WO2025162225A1	PGDB_A009431	PGDB_C024248	PGDB_AS002453	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	CRBN	-	WO2025162225A1	PGDB_A013433	PGDB_C024248	PGDB_AS000750	View
% Inhibition	-	=	40-50	%	10 nM	96 h	IKZF3	-	MM.1S	WO2025162225A1	PGDB_A014123	PGDB_C024248	PGDB_AS002484	View
% Inhibition	-	=	60-70	%	500 nM	96 h	IKZF3	-	MV-4-11	WO2025162225A1	PGDB_A015754	PGDB_C024248	PGDB_AS001561	View
% Inhibition	-	=	50-60	%	10 nM	96 h	IKZF3	-	H196	WO2025162225A1	PGDB_A016754	PGDB_C024248	PGDB_AS001140	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025162225A1	PGDB_A021166	PGDB_C024248	PGDB_AS000351	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025162225A1	PGDB_A034481	PGDB_C024248	PGDB_AS000091	View
% Inhibition	-	=	30-40	%	10 nM	96 h	IKZF3	-	RPMI-8226	WO2025162225A1	PGDB_A035174	PGDB_C024248	PGDB_AS000859	View
% Inhibition	-	=	50-60	%	500 nM	96 h	IKZF3	-	MM.1S	WO2025162225A1	PGDB_A036077	PGDB_C024248	PGDB_AS001942	View
% Inhibition	-	=	40-50	%	10 nM	96 h	IKZF3	-	MV-4-11	WO2025162225A1	PGDB_A043890	PGDB_C024248	PGDB_AS001155	View
% Inhibition	-	=	60-70	%	500 nM	96 h	IKZF3	-	H196	WO2025162225A1	PGDB_A046796	PGDB_C024248	PGDB_AS000866	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	CRBN	-	WO2025162225A1	PGDB_A051217	PGDB_C024248	PGDB_AS001726	View
% Inhibition	-	=	60-70	%	0.5 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A052542	PGDB_C024248	PGDB_AS002133	View
% Inhibition	-	=	50-60	%	500 nM	96 h	IKZF3	-	RPMI-8226	WO2025162225A1	PGDB_A055976	PGDB_C024248	PGDB_AS001812	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025162225A1	PGDB_A059863	PGDB_C024248	PGDB_AS000689	View
% Inhibition	-	=	80-100	%	2 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A073968	PGDB_C024248	PGDB_AS002540	View

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