PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(NN4CCCN(CCCCCCCNC56CC7CC(CC(C7)C5)C6)CC4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C024257

FormulaC35H52N6O3

Molecular weight604.84

InChIKeyWXOIJKJYWNUZJH-UHFFFAOYSA-N

Physicochemical properties

Exact mass604.4101

RDKit cLogP4.29

TPSA97

HBD / HBA3 / 7

Rotatable bonds12

Heavy atoms44

Hetero atoms9

Rings / aromatic8 / 1

Fraction Csp30.74

Formal charge0

Fragments1

Activity compounds and values

Activity records

10 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	CRBN	-	WO2025162225A1	PGDB_A012214	PGDB_C024257	PGDB_AS002453	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025162225A1	PGDB_A019518	PGDB_C024257	PGDB_AS000689	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025162225A1	PGDB_A028273	PGDB_C024257	PGDB_AS000351	View
% Inhibition	-	=	10-20	%	10 nM	96 h	IKZF3	-	TMD8	WO2025162225A1	PGDB_A029171	PGDB_C024257	PGDB_AS000160	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	CRBN	-	WO2025162225A1	PGDB_A039537	PGDB_C024257	PGDB_AS001726	View
% Inhibition	-	=	80-100	%	2 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A042346	PGDB_C024257	PGDB_AS002540	View
% Inhibition	-	=	50-60	%	500 nM	96 h	IKZF3	-	TMD8	WO2025162225A1	PGDB_A055589	PGDB_C024257	PGDB_AS002558	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025162225A1	PGDB_A059722	PGDB_C024257	PGDB_AS000091	View
% Inhibition	-	=	60-70	%	0.5 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A064109	PGDB_C024257	PGDB_AS002133	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	CRBN	-	WO2025162225A1	PGDB_A069845	PGDB_C024257	PGDB_AS000750	View

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