PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(NN4CC5CC(C4)N5CCCCCCCNC45CC6CC(CC(C6)C4)C5)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C024258

FormulaC35H50N6O3

Molecular weight602.824

InChIKeyMNWSFKFFUMYZSB-UHFFFAOYSA-N

Physicochemical properties

Exact mass602.3944

RDKit cLogP4.04

TPSA97

HBD / HBA3 / 7

Rotatable bonds12

Heavy atoms44

Hetero atoms9

Rings / aromatic10 / 1

Fraction Csp30.74

Formal charge0

Fragments1

Activity compounds and values

Activity records

10 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Inhibition	-	=	30-40	%	10 nM	96 h	IKZF3	-	TMD8	WO2025162225A1	PGDB_A017428	PGDB_C024258	PGDB_AS000160	View
% Inhibition	-	=	80-100	%	2 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A032606	PGDB_C024258	PGDB_AS002540	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	CRBN	-	WO2025162225A1	PGDB_A051470	PGDB_C024258	PGDB_AS002453	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	CRBN	-	WO2025162225A1	PGDB_A052067	PGDB_C024258	PGDB_AS000750	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	CRBN	-	WO2025162225A1	PGDB_A055914	PGDB_C024258	PGDB_AS001726	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025162225A1	PGDB_A056355	PGDB_C024258	PGDB_AS000091	View
% Inhibition	-	=	60-70	%	0.5 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A062987	PGDB_C024258	PGDB_AS002133	View
% Inhibition	-	=	70-80	%	500 nM	96 h	IKZF3	-	TMD8	WO2025162225A1	PGDB_A071838	PGDB_C024258	PGDB_AS002558	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025162225A1	PGDB_A073385	PGDB_C024258	PGDB_AS000689	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025162225A1	PGDB_A075748	PGDB_C024258	PGDB_AS000351	View

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