PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(NN4CC5CC4CN5CCCCCCCNC45CC6CC(CC(C6)C4)C5)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C024259

FormulaC35H50N6O3

Molecular weight602.824

InChIKeyQWUWNLLADILZHN-UHFFFAOYSA-N

Physicochemical properties

Exact mass602.3944

RDKit cLogP4.04

TPSA97

HBD / HBA3 / 7

Rotatable bonds12

Heavy atoms44

Hetero atoms9

Rings / aromatic9 / 1

Fraction Csp30.74

Formal charge0

Fragments1

Activity compounds and values

Activity records

10 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025162225A1	PGDB_A036449	PGDB_C024259	PGDB_AS000091	View
% Inhibition	-	=	10-20	%	10 nM	96 h	IKZF3	-	TMD8	WO2025162225A1	PGDB_A037203	PGDB_C024259	PGDB_AS000160	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025162225A1	PGDB_A039866	PGDB_C024259	PGDB_AS000689	View
% Inhibition	-	=	80-100	%	2 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A040960	PGDB_C024259	PGDB_AS002540	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	CRBN	-	WO2025162225A1	PGDB_A048722	PGDB_C024259	PGDB_AS000750	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025162225A1	PGDB_A050200	PGDB_C024259	PGDB_AS000351	View
% Inhibition	-	=	60-70	%	0.5 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A056519	PGDB_C024259	PGDB_AS002133	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	CRBN	-	WO2025162225A1	PGDB_A056687	PGDB_C024259	PGDB_AS002453	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	CRBN	-	WO2025162225A1	PGDB_A062542	PGDB_C024259	PGDB_AS001726	View
% Inhibition	-	=	50-60	%	500 nM	96 h	IKZF3	-	TMD8	WO2025162225A1	PGDB_A076193	PGDB_C024259	PGDB_AS002558	View

Rows per pagePage 1 of 1 · 10 recordsGo to page