PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(NN4CC5CC4CN5C(c4ccc(Cl)cc4)c4ccc(Cl)cc4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C024265

FormulaC31H29Cl2N5O3

Molecular weight590.511

InChIKeyDLFHTDUKENTDMR-UHFFFAOYSA-N

Physicochemical properties

Exact mass589.1647

RDKit cLogP4.63

TPSA85

HBD / HBA2 / 6

Rotatable bonds6

Heavy atoms41

Hetero atoms10

Rings / aromatic7 / 3

Fraction Csp30.32

Formal charge0

Fragments1

Activity compounds and values

Activity records

10 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	CRBN	-	WO2025162225A1	PGDB_A008299	PGDB_C024265	PGDB_AS000750	View
% Inhibition	-	=	30-40	%	10 nM	96 h	IKZF3	-	TMD8	WO2025162225A1	PGDB_A016481	PGDB_C024265	PGDB_AS000160	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	CRBN	-	WO2025162225A1	PGDB_A020377	PGDB_C024265	PGDB_AS002453	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025162225A1	PGDB_A025023	PGDB_C024265	PGDB_AS000351	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025162225A1	PGDB_A026268	PGDB_C024265	PGDB_AS000689	View
% Inhibition	-	=	40-50	%	500 nM	96 h	IKZF3	-	TMD8	WO2025162225A1	PGDB_A027335	PGDB_C024265	PGDB_AS002558	View
% Inhibition	-	=	70-80	%	2 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A040309	PGDB_C024265	PGDB_AS002540	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025162225A1	PGDB_A045778	PGDB_C024265	PGDB_AS000091	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	CRBN	-	WO2025162225A1	PGDB_A058651	PGDB_C024265	PGDB_AS001726	View
% Inhibition	-	=	40-53	%	0.5 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A072856	PGDB_C024265	PGDB_AS002133	View

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