PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(NN4CCCN(Cc5ccc(-c6ccco6)s5)CC4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C024356

FormulaC27H29N5O4S

Molecular weight519.627

InChIKeyHMRWEDBJXBBPLK-UHFFFAOYSA-N

Physicochemical properties

Exact mass519.194

RDKit cLogP3.3

TPSA98.1

HBD / HBA2 / 8

Rotatable bonds6

Heavy atoms37

Hetero atoms10

Rings / aromatic6 / 3

Fraction Csp30.37

Formal charge0

Fragments1

Activity compounds and values

Activity records

14 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Inhibition	-	=	40-50	%	500 nM	96 h	IKZF3	-	MV-4-11	WO2025162225A1	PGDB_A011719	PGDB_C024356	PGDB_AS001561	View
% Inhibition	-	=	30-40	%	10 nM	96 h	IKZF3	-	MV-4-11	WO2025162225A1	PGDB_A014705	PGDB_C024356	PGDB_AS001155	View
% Inhibition	-	=	20-30	%	10 nM	96 h	IKZF3	-	CFPAC-1	WO2025162225A1	PGDB_A014728	PGDB_C024356	PGDB_AS000245	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	CRBN	-	WO2025162225A1	PGDB_A021687	PGDB_C024356	PGDB_AS002453	View
% Inhibition	-	=	30-40	%	10 nM	96 h	IKZF3	-	H196	WO2025162225A1	PGDB_A026174	PGDB_C024356	PGDB_AS001140	View
% Inhibition	-	=	40-50	%	500 nM	96 h	IKZF3	-	H196	WO2025162225A1	PGDB_A028694	PGDB_C024356	PGDB_AS000866	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025162225A1	PGDB_A037152	PGDB_C024356	PGDB_AS000091	View
% Inhibition	-	=	80-100	%	2 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A041382	PGDB_C024356	PGDB_AS002540	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	CRBN	-	WO2025162225A1	PGDB_A045203	PGDB_C024356	PGDB_AS001726	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025162225A1	PGDB_A051897	PGDB_C024356	PGDB_AS000351	View
% Inhibition	-	=	70-80	%	0.5 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A057970	PGDB_C024356	PGDB_AS002133	View
% Inhibition	-	=	50-60	%	500 nM	96 h	IKZF3	-	CFPAC-1	WO2025162225A1	PGDB_A058372	PGDB_C024356	PGDB_AS000857	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025162225A1	PGDB_A060957	PGDB_C024356	PGDB_AS000689	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	CRBN	-	WO2025162225A1	PGDB_A063506	PGDB_C024356	PGDB_AS000750	View

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