PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(NN4CCCN(CC5=C(c6ccc(Cl)cc6)CCC(F)(F)C5)CC4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C024378

FormulaC31H34ClF2N5O3

Molecular weight598.094

InChIKeyWGWAXFFQNVGPKU-UHFFFAOYSA-N

Physicochemical properties

Exact mass597.2318

RDKit cLogP4.71

TPSA85

HBD / HBA2 / 6

Rotatable bonds6

Heavy atoms42

Hetero atoms11

Rings / aromatic6 / 2

Fraction Csp30.45

Formal charge0

Fragments1

Activity compounds and values

Activity records

10 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Inhibition	-	=	30-40	%	10 nM	96 h	IKZF3	-	H196	WO2025162225A1	PGDB_A019268	PGDB_C024378	PGDB_AS001140	View
% Inhibition	-	=	20-30	%	0.5 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A021316	PGDB_C024378	PGDB_AS002133	View
% Inhibition	-	=	53-60	%	2 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A030298	PGDB_C024378	PGDB_AS002540	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025162225A1	PGDB_A044574	PGDB_C024378	PGDB_AS000091	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	CRBN	-	WO2025162225A1	PGDB_A048920	PGDB_C024378	PGDB_AS000750	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	CRBN	-	WO2025162225A1	PGDB_A053700	PGDB_C024378	PGDB_AS002453	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025162225A1	PGDB_A056310	PGDB_C024378	PGDB_AS000689	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	CRBN	-	WO2025162225A1	PGDB_A060092	PGDB_C024378	PGDB_AS001726	View
% Inhibition	-	=	40-50	%	500 nM	96 h	IKZF3	-	H196	WO2025162225A1	PGDB_A063261	PGDB_C024378	PGDB_AS000866	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025162225A1	PGDB_A076674	PGDB_C024378	PGDB_AS000351	View

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