PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(NN4CC5CC4CN5CC4=C(c5ccc(F)cc5)CCCC4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C024395

FormulaC31H34FN5O3

Molecular weight543.643

InChIKeyGLUXKHGVCMGDPD-UHFFFAOYSA-N

Physicochemical properties

Exact mass543.2646

RDKit cLogP3.7

TPSA85

HBD / HBA2 / 6

Rotatable bonds6

Heavy atoms40

Hetero atoms9

Rings / aromatic7 / 2

Fraction Csp30.45

Formal charge0

Fragments1

Activity compounds and values

Activity records

12 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025162225A1	PGDB_A010840	PGDB_C024395	PGDB_AS000351	View
% Inhibition	-	=	60-70	%	0.5 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A027919	PGDB_C024395	PGDB_AS002133	View
% Inhibition	-	=	80-100	%	2 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A028723	PGDB_C024395	PGDB_AS002540	View
% Inhibition	-	=	40-50	%	500 nM	96 h	IKZF3	-	MV-4-11	WO2025162225A1	PGDB_A036441	PGDB_C024395	PGDB_AS001561	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	CRBN	-	WO2025162225A1	PGDB_A041782	PGDB_C024395	PGDB_AS002453	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025162225A1	PGDB_A068477	PGDB_C024395	PGDB_AS000689	View
% Inhibition	-	=	40-50	%	10 nM	96 h	IKZF3	-	H196	WO2025162225A1	PGDB_A070205	PGDB_C024395	PGDB_AS001140	View
% Inhibition	-	=	40-50	%	10 nM	96 h	IKZF3	-	MV-4-11	WO2025162225A1	PGDB_A071117	PGDB_C024395	PGDB_AS001155	View
% Inhibition	-	=	50-60	%	500 nM	96 h	IKZF3	-	H196	WO2025162225A1	PGDB_A071752	PGDB_C024395	PGDB_AS000866	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	CRBN	-	WO2025162225A1	PGDB_A073638	PGDB_C024395	PGDB_AS001726	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	CRBN	-	WO2025162225A1	PGDB_A074195	PGDB_C024395	PGDB_AS000750	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025162225A1	PGDB_A075626	PGDB_C024395	PGDB_AS000091	View

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