PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(NN4C5CCC4CN(Cc4ccccc4-c4ccc(Cl)cc4)C5)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C024403

FormulaC32H32ClN5O3

Molecular weight570.093

InChIKeyCBPLMHDBDUHVGH-UHFFFAOYSA-N

Physicochemical properties

Exact mass569.2194

RDKit cLogP4.44

TPSA85

HBD / HBA2 / 6

Rotatable bonds6

Heavy atoms41

Hetero atoms9

Rings / aromatic7 / 3

Fraction Csp30.34

Formal charge0

Fragments1

Activity compounds and values

Activity records

10 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Inhibition	-	=	60-70	%	500 nM	96 h	IKZF3	-	H196	WO2025162225A1	PGDB_A019055	PGDB_C024403	PGDB_AS000866	View
% Inhibition	-	=	60-70	%	10 nM	96 h	IKZF3	-	H196	WO2025162225A1	PGDB_A028704	PGDB_C024403	PGDB_AS001140	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	CRBN	-	WO2025162225A1	PGDB_A029201	PGDB_C024403	PGDB_AS001726	View
% Inhibition	-	=	60-70	%	2 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A036560	PGDB_C024403	PGDB_AS002540	View
% Inhibition	-	=	20-30	%	0.5 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A038833	PGDB_C024403	PGDB_AS002133	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025162225A1	PGDB_A051465	PGDB_C024403	PGDB_AS000689	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025162225A1	PGDB_A063079	PGDB_C024403	PGDB_AS000091	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	CRBN	-	WO2025162225A1	PGDB_A064504	PGDB_C024403	PGDB_AS002453	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	CRBN	-	WO2025162225A1	PGDB_A065289	PGDB_C024403	PGDB_AS000750	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025162225A1	PGDB_A075432	PGDB_C024403	PGDB_AS000351	View

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