Loading compound
Loading detail record from the SQLite release...
Compound
PGDB_C024417
10 activity records1 related patents
2D structure
O=C1CCC(N2Cc3cc(NN4CC5CC4CN5C(c4ccccc4F)c4ccccc4F)ccc3C2=O)C(=O)N1Compound summary
Physicochemical properties
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| % Degradation | - | = | 20-100 | % | Concentration series: 500 nM, 50 nM | 24 h | CSNK1A1 | - | - | WO2025162225A1 | PGDB_A014762 | PGDB_C024417 | PGDB_AS000689 | View |
| % Degradation | - | = | 20-100 | % | Concentration series: 500 nM, 50 nM | 24 h | GSPT1 | CRBN | - | WO2025162225A1 | PGDB_A016505 | PGDB_C024417 | PGDB_AS001726 | View |
| % Inhibition | - | = | 80-100 | % | 2 uM | - | CRBN | CRBN | - | WO2025162225A1 | PGDB_A022052 | PGDB_C024417 | PGDB_AS002540 | View |
| % Inhibition | - | = | 40-50 | % | 500 nM | 96 h | IKZF3 | - | H196 | WO2025162225A1 | PGDB_A024181 | PGDB_C024417 | PGDB_AS000866 | View |
| % Degradation | - | = | 20-100 | % | Concentration series: 500 nM, 50 nM | 24 h | WEE1 | - | - | WO2025162225A1 | PGDB_A027649 | PGDB_C024417 | PGDB_AS000091 | View |
| % Inhibition | - | = | 80-100 | % | 0.5 uM | - | CRBN | CRBN | - | WO2025162225A1 | PGDB_A034335 | PGDB_C024417 | PGDB_AS002133 | View |
| % Inhibition | - | = | 20-30 | % | 10 nM | 96 h | IKZF3 | - | H196 | WO2025162225A1 | PGDB_A058244 | PGDB_C024417 | PGDB_AS001140 | View |
| % Degradation | - | = | 20-100 | % | Concentration series: 500 nM, 50 nM | 24 h | IKZF3 | - | - | WO2025162225A1 | PGDB_A068437 | PGDB_C024417 | PGDB_AS000351 | View |
| % Degradation | - | = | 0-20 | % | Concentration series: 500 nM, 50 nM | 24 h | IKZF1 | CRBN | - | WO2025162225A1 | PGDB_A073059 | PGDB_C024417 | PGDB_AS002453 | View |
| % Degradation | - | = | 0-20 | % | Concentration series: 500 nM, 50 nM | 24 h | IKZF2 | CRBN | - | WO2025162225A1 | PGDB_A075307 | PGDB_C024417 | PGDB_AS000750 | View |