PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(NN4CC5CC(C4)N5C(c4ccccc4)c4ccccn4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C024421

FormulaC30H30N6O3

Molecular weight522.609

InChIKeyDTKWXZRFYPDRHP-UHFFFAOYSA-N

Physicochemical properties

Exact mass522.2379

RDKit cLogP2.72

TPSA97.9

HBD / HBA2 / 7

Rotatable bonds6

Heavy atoms39

Hetero atoms9

Rings / aromatic8 / 3

Fraction Csp30.33

Formal charge0

Fragments1

Activity compounds and values

Activity records

12 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	CRBN	-	WO2025162225A1	PGDB_A007415	PGDB_C024421	PGDB_AS000750	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025162225A1	PGDB_A010276	PGDB_C024421	PGDB_AS000689	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	CRBN	-	WO2025162225A1	PGDB_A012596	PGDB_C024421	PGDB_AS001726	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	CRBN	-	WO2025162225A1	PGDB_A021387	PGDB_C024421	PGDB_AS002453	View
% Inhibition	-	=	50-60	%	10 nM	96 h	IKZF3	-	H196	WO2025162225A1	PGDB_A022514	PGDB_C024421	PGDB_AS001140	View
% Inhibition	-	=	70-80	%	0.5 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A023664	PGDB_C024421	PGDB_AS002133	View
% Inhibition	-	=	60-70	%	500 nM	96 h	IKZF3	-	MV-4-11	WO2025162225A1	PGDB_A025732	PGDB_C024421	PGDB_AS001561	View
% Inhibition	-	=	80-100	%	2 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A044694	PGDB_C024421	PGDB_AS002540	View
% Inhibition	-	=	40-50	%	10 nM	96 h	IKZF3	-	MV-4-11	WO2025162225A1	PGDB_A054734	PGDB_C024421	PGDB_AS001155	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025162225A1	PGDB_A061044	PGDB_C024421	PGDB_AS000091	View
% Inhibition	-	=	50-60	%	500 nM	96 h	IKZF3	-	H196	WO2025162225A1	PGDB_A061125	PGDB_C024421	PGDB_AS000866	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025162225A1	PGDB_A068212	PGDB_C024421	PGDB_AS000351	View

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