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Compound
PGDB_C024617
12 activity records1 related patents
2D structure
CCN(C)C(=O)C(C)(C)C#Cc1cnc([C@H](C)OC)c(-c2c3c4cc(ccc4n2CC)-c2csc(n2)C[C@H](NC(=O)[C@H]2[C@H](C)[C@@H]2C)C(=O)N2CCC[C@H](N2)C(=O)OCC(C)(C)C3)c1Compound summary
Physicochemical properties
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IC50 | - | = | 1.112 | nM | - | — | KRAS | - | AGS | CN121181579A | PGDB_A013129 | PGDB_C024617 | PGDB_AS000782 | View |
| IC50 | - | > | 1000 | nM | - | — | BRAF | - | A375 | CN121181579A | PGDB_A016821 | PGDB_C024617 | PGDB_AS002189 | View |
| IC50 | - | <= | 10 | nM | - | — | KRAS | - | AsPC-1 | CN121181579A | PGDB_A022105 | PGDB_C024617 | PGDB_AS001095 | View |
| IC50 | - | = | 0.3664 | nM | - | — | KRAS | - | SW620 | CN121181579A | PGDB_A033537 | PGDB_C024617 | PGDB_AS001545 | View |
| IC50 | - | <= | 10 | nM | - | — | KRAS | - | HPAC | CN121181579A | PGDB_A039689 | PGDB_C024617 | PGDB_AS000097 | View |
| IC50 | - | = | 3.429 | nM | - | — | KRAS | - | - | CN121181579A | PGDB_A042227 | PGDB_C024617 | PGDB_AS000377 | View |
| IC50 | - | = | 8.374 | nM | - | — | KRAS | - | - | CN121181579A | PGDB_A052252 | PGDB_C024617 | PGDB_AS000617 | View |
| IC50 | - | <= | 10 | nM | - | — | KRAS | - | AGS | CN121181579A | PGDB_A058185 | PGDB_C024617 | PGDB_AS000586 | View |
| IC50 | - | <= | 10 | nM | - | — | - | - | MIA PaCa-2 | CN121181579A | PGDB_A067430 | PGDB_C024617 | PGDB_AS001225 | View |
| IC50 | - | = | 0.9378 | nM | - | — | KRAS | - | AsPC-1 | CN121181579A | PGDB_A068037 | PGDB_C024617 | PGDB_AS001203 | View |
| IC50 | - | <= | 10 | nM | - | — | KRAS | - | NCI-H358 | CN121181579A | PGDB_A069974 | PGDB_C024617 | PGDB_AS000504 | View |
| IC50 | - | = | 0.5622 | nM | - | — | KRAS | - | NCI-H358 | CN121181579A | PGDB_A070655 | PGDB_C024617 | PGDB_AS002403 | View |