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Compound
PGDB_C024627
12 activity records1 related patents
2D structure
CCN1CCN(C(=O)C(C)(C)C#Cc2cnc([C@H](C)OC)c(-c3c4c5cc(ccc5n3CC)-c3csc(n3)C[C@H](NC(=O)[C@H]3[C@H](C)[C@@H]3C)C(=O)N3N[C@H](C(=O)OCC(C)(C)C4)C4CC3C4)c2)CC1Compound summary
Physicochemical properties
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IC50 | - | <= | 10 | nM | - | — | KRAS | - | AGS | CN121181579A | PGDB_A007215 | PGDB_C024627 | PGDB_AS000586 | View |
| IC50 | - | <= | 10 | nM | - | — | KRAS | - | NCI-H358 | CN121181579A | PGDB_A009161 | PGDB_C024627 | PGDB_AS000504 | View |
| IC50 | - | = | 0.1795 | nM | - | — | KRAS | - | SW620 | CN121181579A | PGDB_A015548 | PGDB_C024627 | PGDB_AS001545 | View |
| IC50 | - | = | 8.405 | nM | - | — | KRAS | - | - | CN121181579A | PGDB_A019371 | PGDB_C024627 | PGDB_AS000377 | View |
| IC50 | - | <= | 10 | nM | - | — | - | - | MIA PaCa-2 | CN121181579A | PGDB_A023613 | PGDB_C024627 | PGDB_AS001225 | View |
| IC50 | - | = | 0.4719 | nM | - | — | KRAS | - | NCI-H358 | CN121181579A | PGDB_A045275 | PGDB_C024627 | PGDB_AS002403 | View |
| IC50 | - | <= | 10 | nM | - | — | KRAS | - | HPAC | CN121181579A | PGDB_A054918 | PGDB_C024627 | PGDB_AS000097 | View |
| IC50 | - | <= | 10 | nM | - | — | KRAS | - | AsPC-1 | CN121181579A | PGDB_A066370 | PGDB_C024627 | PGDB_AS001095 | View |
| IC50 | - | = | 0.6777 | nM | - | — | KRAS | - | AGS | CN121181579A | PGDB_A067652 | PGDB_C024627 | PGDB_AS000782 | View |
| IC50 | - | = | 1.579 | nM | - | — | KRAS | - | AsPC-1 | CN121181579A | PGDB_A069727 | PGDB_C024627 | PGDB_AS001203 | View |
| IC50 | - | > | 1000 | nM | - | — | BRAF | - | A375 | CN121181579A | PGDB_A073196 | PGDB_C024627 | PGDB_AS002189 | View |
| IC50 | - | = | 23.35 | nM | - | — | KRAS | - | - | CN121181579A | PGDB_A076459 | PGDB_C024627 | PGDB_AS000617 | View |