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Compound
PGDB_C024673
12 activity records1 related patents
2D structure
COC(C)c1ncc(C#CC(C)(C)C(=O)N(C)C)cc1-c1c2c3cc(ccc3n1CC(F)(F)F)-c1csc(n1)CC(NC(=O)C1C(C)C1C)C(=O)N1NC(C(=O)OCC(C)(C)C2)C2CC1C2Compound summary
Physicochemical properties
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IC50 | - | > | 1000 | nM | - | — | BRAF | - | A375 | CN121181579A | PGDB_A008504 | PGDB_C024673 | PGDB_AS002189 | View |
| IC50 | - | = | 0.08517 | nM | - | — | KRAS | - | SW620 | CN121181579A | PGDB_A024975 | PGDB_C024673 | PGDB_AS001545 | View |
| IC50 | - | <= | 10 | nM | - | — | KRAS | - | NCI-H358 | CN121181579A | PGDB_A029260 | PGDB_C024673 | PGDB_AS000504 | View |
| IC50 | - | = | 6.028 | nM | - | — | KRAS | - | - | CN121181579A | PGDB_A030435 | PGDB_C024673 | PGDB_AS000617 | View |
| IC50 | - | <= | 10 | nM | - | — | KRAS | - | HPAC | CN121181579A | PGDB_A030602 | PGDB_C024673 | PGDB_AS000097 | View |
| IC50 | - | = | 4.899 | nM | - | — | KRAS | - | - | CN121181579A | PGDB_A031210 | PGDB_C024673 | PGDB_AS000377 | View |
| IC50 | - | <= | 10 | nM | - | — | KRAS | - | AGS | CN121181579A | PGDB_A040361 | PGDB_C024673 | PGDB_AS000586 | View |
| IC50 | - | = | 0.6642 | nM | - | — | KRAS | - | AGS | CN121181579A | PGDB_A041343 | PGDB_C024673 | PGDB_AS000782 | View |
| IC50 | - | = | 0.3578 | nM | - | — | KRAS | - | AsPC-1 | CN121181579A | PGDB_A043590 | PGDB_C024673 | PGDB_AS001203 | View |
| IC50 | - | = | 0.6771 | nM | - | — | KRAS | - | NCI-H358 | CN121181579A | PGDB_A048579 | PGDB_C024673 | PGDB_AS002403 | View |
| IC50 | - | <= | 10 | nM | - | — | KRAS | - | AsPC-1 | CN121181579A | PGDB_A070950 | PGDB_C024673 | PGDB_AS001095 | View |
| IC50 | - | <= | 10 | nM | - | — | - | - | MIA PaCa-2 | CN121181579A | PGDB_A077552 | PGDB_C024673 | PGDB_AS001225 | View |