PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberAU2020392427A1

AssigneeCaptor Therapeutics

TitlePiperidine-2, 6-dione derivatives which bind to cereblon, and methods of use thereof

Family ID69024572

Family members8

Filing year2020

Publication date2022-06-16

JurisdictionAU

Compounds46

Activity records70

Assays5

Activity compounds and values

Activity records

70 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
Ki	-	=	1-10	uM	-	—	CRBN	CRBN	-	PGDB_A007164	PGDB_C019055	PGDB_AS000153	View
% Degradation	-	<=	25	%	20 uM	24 h	CSNK1A1	-	NCI-H929	PGDB_A009266	PGDB_C019025	PGDB_AS000343	View
% Degradation	-	<=	25	%	20 uM	24 h	IKZF1	CRBN	NCI-H929	PGDB_A011398	PGDB_C019016	PGDB_AS000227	View
Ki	-	=	1-10	uM	-	—	CRBN	CRBN	-	PGDB_A011501	PGDB_C019045	PGDB_AS000153	View
% Degradation	-	<=	25	%	20 uM	24 h	SALL4	-	NCI-H929	PGDB_A011990	PGDB_C019040	PGDB_AS002409	View
Ki	-	<=	1	uM	-	—	CRBN	CRBN	-	PGDB_A017100	PGDB_C019038	PGDB_AS000153	View
Ki	-	=	1-10	uM	-	—	CRBN	CRBN	-	PGDB_A017416	PGDB_C019047	PGDB_AS000153	View
Ki	-	=	1-10	uM	-	—	CRBN	CRBN	-	PGDB_A018383	PGDB_C008731	PGDB_AS000153	View
% Degradation	-	<=	25	%	20 uM	24 h	IKZF1	CRBN	NCI-H929	PGDB_A018685	PGDB_C019027	PGDB_AS000227	View
Ki	-	=	1-10	uM	-	—	CRBN	CRBN	-	PGDB_A018843	PGDB_C019039	PGDB_AS000153	View
Ki	-	=	10-50	uM	-	—	CRBN	CRBN	-	PGDB_A019498	PGDB_C019056	PGDB_AS000153	View
Ki	-	=	1-10	uM	-	—	CRBN	CRBN	-	PGDB_A019667	PGDB_C019053	PGDB_AS000153	View
% Degradation	-	<=	25	%	20 uM	24 h	SALL4	-	NCI-H929	PGDB_A020246	PGDB_C019020	PGDB_AS002409	View
Ki	-	=	1-10	uM	-	—	CRBN	CRBN	-	PGDB_A020675	PGDB_C019036	PGDB_AS000153	View
% Degradation	-	<=	25	%	20 uM	24 h	CSNK1A1	-	NCI-H929	PGDB_A021571	PGDB_C019016	PGDB_AS000343	View
Ki	-	=	1-10	uM	-	—	CRBN	CRBN	-	PGDB_A023471	PGDB_C019051	PGDB_AS000153	View
Ki	-	=	10-50	uM	-	—	CRBN	CRBN	-	PGDB_A023774	PGDB_C019043	PGDB_AS000153	View
Ki	-	<=	1	uM	-	—	CRBN	CRBN	-	PGDB_A024651	PGDB_C019062	PGDB_AS000153	View
% Degradation	-	<=	25	%	20 uM	24 h	CSNK1A1	-	NCI-H929	PGDB_A025355	PGDB_C019028	PGDB_AS000343	View
% Degradation	-	<=	25	%	20 uM	24 h	IKZF3	-	NCI-H929	PGDB_A025818	PGDB_C019040	PGDB_AS001550	View

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