PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberAU2021361043A9

AssigneeC4 Therapeutics

TitleTricyclic ligands for degradation of ikzf2 or ikzf4

Family ID81208646

Family members12

Filing year2021

Publication date2025-03-13

JurisdictionAU

Compounds26

Activity records92

Assays10

Activity compounds and values

Activity records

92 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
Emax	-	=	60-95	%	10 uM	DC50 > 10000 nM	GSPT1	-	293T.114	PGDB_A008798	PGDB_C016642	PGDB_AS000916	View
Emax	-	=	60-95	%	10 uM	DC50 > 10000 nM	IKZF2	-	JURKAT.21	PGDB_A009073	PGDB_C019158	PGDB_AS001733	View
Emax	-	=	60-95	%	-	-	IKZF2	-	-	PGDB_A009186	PGDB_C016640	PGDB_AS000275	View
Emax	-	=	60-95	%	10 uM	DC50 > 10000 nM	IKZF2	-	JURKAT.21	PGDB_A009903	PGDB_C019167	PGDB_AS001733	View
Emax	-	=	60-95	%	10 uM	DC50 > 10000 nM	GSPT1	-	293T.114	PGDB_A010699	PGDB_C019162	PGDB_AS000916	View
Emax	-	>	95	%	10 uM	DC50 > 10000 nM	GSPT1	-	293T.114	PGDB_A011049	PGDB_C019154	PGDB_AS000916	View
DC50	-	>	10000	nM	-	—	IKZF2	-	JURKAT.21	PGDB_A012031	PGDB_C019170	PGDB_AS000724	View
Emax	-	=	60-95	%	10 uM	DC50 > 10000 nM	IKZF2	-	JURKAT.21	PGDB_A012609	PGDB_C016643	PGDB_AS001733	View
DC50	-	>	10000	nM	-	—	IKZF2	-	JURKAT.21	PGDB_A012677	PGDB_C019171	PGDB_AS000724	View
Emax	-	=	60-95	%	10 uM	DC50 > 10000 nM	IKZF2	-	JURKAT.21	PGDB_A012775	PGDB_C016651	PGDB_AS001733	View
DC50	-	>	10000	nM	-	—	IKZF2	-	JURKAT.21	PGDB_A013192	PGDB_C019156	PGDB_AS000724	View
Emax	-	>	95	%	-	-	IKZF2	-	-	PGDB_A014355	PGDB_C016640	PGDB_AS000347	View
Emax	-	=	60-95	%	10 uM	DC50 > 10000 nM	IKZF2	-	JURKAT.21	PGDB_A015038	PGDB_C019157	PGDB_AS001733	View
DC50	-	>	10000	nM	-	—	IKZF2	-	JURKAT.21	PGDB_A015246	PGDB_C019152	PGDB_AS000724	View
Emax	-	=	60-95	%	10 uM	DC50 > 10000 nM	IKZF2	-	JURKAT.21	PGDB_A015467	PGDB_C019164	PGDB_AS001733	View
DC50	-	>	10000	nM	-	—	IKZF2	-	JURKAT.21	PGDB_A015772	PGDB_C016651	PGDB_AS000724	View
Emax	-	<	45	%	-	-	IKZF2	-	-	PGDB_A016404	PGDB_C016642	PGDB_AS000275	View
DC50	-	>	10000	nM	-	—	GSPT1	-	293T.114	PGDB_A016417	PGDB_C019161	PGDB_AS002445	View
Emax	-	=	60-95	%	10 uM	DC50 > 10000 nM	IKZF2	-	JURKAT.21	PGDB_A017454	PGDB_C019152	PGDB_AS001733	View
DC50	-	>	10000	nM	-	—	IKZF2	-	JURKAT.21	PGDB_A019727	PGDB_C019154	PGDB_AS000724	View

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