PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberCN115260206A

AssigneeMinghui Pharmaceutical Hangzhou, Minghui Pharmaceutical Shanghai

TitleEstrogen receptor degradation agent, intermediate thereof, preparation method, pharmaceutical composition and application

Family ID83759398

Family members1

Filing year2022

Publication date2022-11-01

JurisdictionCN

Compounds8

Activity records18

Assays3

Activity compounds and values

Activity records

18 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
IC50	-	=	5.2	nM	-	—	ESR1	-	HEK293	PGDB_A008502	PGDB_C006617	PGDB_AS000727	View
IC50	-	=	0.36	nM	-	—	ESR1	-	MCF-7	PGDB_A008610	PGDB_C006617	PGDB_AS001594	View
IC50	-	=	10.1	nM	-	—	ESR1	-	HEK293	PGDB_A010851	PGDB_C006615	PGDB_AS000727	View
IC50	-	=	8.7	nM	-	—	ESR1	-	HEK293	PGDB_A014817	PGDB_C006613	PGDB_AS000727	View
IC50	-	=	0.18	nM	-	—	ESR1	-	MCF-7	PGDB_A021093	PGDB_C006618	PGDB_AS001594	View
IC50	-	=	0.89	nM	-	—	ESR1	-	MCF-7	PGDB_A022645	PGDB_C006613	PGDB_AS001594	View
GI50	-	=	0.1	nM	-	—	ESR1	-	MCF-7	PGDB_A023365	PGDB_C006618	PGDB_AS001900	View
IC50	-	=	14.5	nM	-	—	ESR1	-	HEK293	PGDB_A030709	PGDB_C006620	PGDB_AS000727	View
IC50	-	=	0.69	nM	-	—	ESR1	-	MCF-7	PGDB_A030883	PGDB_C006614	PGDB_AS001594	View
IC50	-	=	1.5	nM	-	—	ESR1	-	MCF-7	PGDB_A038756	PGDB_C006619	PGDB_AS001594	View
IC50	-	=	9.1	nM	-	—	ESR1	-	HEK293	PGDB_A039781	PGDB_C006614	PGDB_AS000727	View
IC50	-	=	1	nM	-	—	ESR1	-	MCF-7	PGDB_A051669	PGDB_C006616	PGDB_AS001594	View
IC50	-	=	4.9	nM	-	—	ESR1	-	HEK293	PGDB_A052245	PGDB_C006618	PGDB_AS000727	View
GI50	-	=	0.24	nM	-	—	ESR1	-	MCF-7	PGDB_A055381	PGDB_C006620	PGDB_AS001900	View
IC50	-	=	13.2	nM	-	—	ESR1	-	HEK293	PGDB_A065365	PGDB_C006619	PGDB_AS000727	View
IC50	-	=	0.32	nM	-	—	ESR1	-	MCF-7	PGDB_A066766	PGDB_C006620	PGDB_AS001594	View
IC50	-	=	1.1	nM	-	—	ESR1	-	MCF-7	PGDB_A068762	PGDB_C006615	PGDB_AS001594	View
IC50	-	=	7.3	nM	-	—	ESR1	-	HEK293	PGDB_A074912	PGDB_C006616	PGDB_AS000727	View

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