PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberCN121471230A

AssigneeGuangdong Hongye Pharmaceutical Technology, Shanghai Institute Of Materia Medica Of Cas

TitleHeterocyclic substituted isoindoline compound, preparation method, pharmaceutical composition and application thereof

Family ID98616296

Family members1

Filing year2025

Publication date2026-02-06

JurisdictionCN

Compounds24

Activity records104

Assays7

Activity compounds and values

Activity records

104 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
Dmax	-	>	80	%	-	16 h	CSNK1A1	-	MV-4-11	PGDB_A007026	PGDB_C001062	PGDB_AS001131	View
IC50	-	<	60	nM	-	—	-	-	MV-4-11	PGDB_A007064	PGDB_C001050	PGDB_AS000948	View
% Degradation	-	<	25	%	1 uM	16 h	GSPT1	-	MV-4-11	PGDB_A007088	PGDB_C001053	PGDB_AS000062	View
% Degradation	-	<	25	%	1 uM	16 h	GSPT1	-	MV-4-11	PGDB_A007152	PGDB_C001050	PGDB_AS000062	View
IC50	-	<	60	nM	-	—	-	-	MV-4-11	PGDB_A007226	PGDB_C001069	PGDB_AS000948	View
Dmax	-	<	60	%	-	16 h	IKZF1	-	MV-4-11	PGDB_A007537	PGDB_C001060	PGDB_AS000264	View
Dmax	-	=	60-80	%	-	16 h	IKZF1	-	MV-4-11	PGDB_A007977	PGDB_C001057	PGDB_AS000264	View
IC50	-	<	60	nM	-	—	-	-	MV-4-11	PGDB_A008618	PGDB_C001067	PGDB_AS000948	View
DC50	-	<	10	nM	-	—	CSNK1A1	-	MV-4-11	PGDB_A009050	PGDB_C001054	PGDB_AS001026	View
% Degradation	-	<	25	%	-	16 h	GSPT1	-	MV-4-11	PGDB_A009860	PGDB_C001059	PGDB_AS000065	View
DC50	-	<	10	nM	-	—	CSNK1A1	-	MV-4-11	PGDB_A011335	PGDB_C001061	PGDB_AS001026	View
Dmax	-	<	60	%	-	16 h	IKZF1	-	MV-4-11	PGDB_A011397	PGDB_C001053	PGDB_AS000264	View
DC50	-	<	10	nM	-	—	CSNK1A1	-	MV-4-11	PGDB_A011590	PGDB_C001059	PGDB_AS001026	View
% Degradation	-	<	25	%	1 uM	16 h	GSPT1	-	MV-4-11	PGDB_A012458	PGDB_C001049	PGDB_AS000062	View
Dmax	-	<	60	%	-	16 h	IKZF1	-	MV-4-11	PGDB_A013197	PGDB_C001046	PGDB_AS000264	View
% Degradation	-	<	25	%	-	16 h	GSPT1	-	MV-4-11	PGDB_A014909	PGDB_C001063	PGDB_AS000065	View
DC50	-	=	100-1000	nM	-	—	IKZF1	-	MV-4-11	PGDB_A014910	PGDB_C001060	PGDB_AS000050	View
Dmax	-	<	60	%	-	16 h	IKZF1	-	MV-4-11	PGDB_A014954	PGDB_C001062	PGDB_AS000264	View
Dmax	-	>	80	%	-	16 h	CSNK1A1	-	MV-4-11	PGDB_A015414	PGDB_C001046	PGDB_AS001131	View
Dmax	-	>	80	%	-	16 h	CSNK1A1	-	MV-4-11	PGDB_A015626	PGDB_C001056	PGDB_AS001131	View

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