PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberUS20230265071A1

AssigneePlexium

TitleAryl compounds and pharmaceutical compositions that modulate ikzf2

Family ID82703117

Family members13

Filing year2022

Publication date2024-05-15

JurisdictionUS

Compounds95

Activity records239

Assays7

Activity compounds and values

Activity records

239 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
DC50	-	>	30	uM	-	—	GSPT1	-	HEK293T	PGDB_A007005	PGDB_C000471	PGDB_AS000322	View
EC50	-	=	0.239	uM	-	—	CRBN	CRBN	-	PGDB_A007218	PGDB_C000405	PGDB_AS001482	View
EC50	-	=	0.022	uM	-	—	CRBN	CRBN	-	PGDB_A007490	PGDB_C000397	PGDB_AS001482	View
DC50	-	>	30	uM	-	—	IKZF1	-	HEK293T	PGDB_A007497	PGDB_C000380	PGDB_AS000960	View
DC50	-	>	30	uM	-	—	GSPT1	-	HEK293T	PGDB_A007616	PGDB_C000472	PGDB_AS000322	View
DC50	-	>	30	uM	-	—	IKZF1	-	HEK293T	PGDB_A007860	PGDB_C000389	PGDB_AS000960	View
DC50	-	=	0.024	uM	-	—	IKZF2	-	HEK293T	PGDB_A007882	PGDB_C000380	PGDB_AS002469	View
EC50	-	=	0.921	uM	-	—	CRBN	CRBN	-	PGDB_A008205	PGDB_C000429	PGDB_AS001482	View
EC50	-	=	0.006	uM	-	—	CRBN	CRBN	-	PGDB_A008232	PGDB_C000406	PGDB_AS001482	View
DC50	-	>	30	uM	-	—	IKZF2	-	HEK293T	PGDB_A008252	PGDB_C000383	PGDB_AS002469	View
EC50	-	>	10	uM	-	—	CRBN	CRBN	-	PGDB_A008316	PGDB_C000438	PGDB_AS001482	View
% Degradation	-	<	15	%	1 uM	24 h	IKZF2	-	HEK293T	PGDB_A009006	PGDB_C000451	PGDB_AS000278	View
EC50	-	=	0.02	uM	-	—	CRBN	CRBN	-	PGDB_A009485	PGDB_C004617	PGDB_AS001482	View
% Degradation	-	=	32.7	%	1 uM	24 h	IKZF2	-	HEK293T	PGDB_A009659	PGDB_C000408	PGDB_AS000278	View
EC50	-	=	6.81	uM	-	—	CRBN	CRBN	-	PGDB_A009733	PGDB_C000435	PGDB_AS001482	View
% Degradation	-	=	84.9	%	1 uM	24 h	IKZF2	-	HEK293T	PGDB_A010311	PGDB_C000409	PGDB_AS000278	View
EC50	-	=	0.042	uM	-	—	CRBN	CRBN	-	PGDB_A010658	PGDB_C000442	PGDB_AS001482	View
EC50	-	=	0.045	uM	-	—	CRBN	CRBN	-	PGDB_A010776	PGDB_C000399	PGDB_AS001482	View
EC50	-	=	0.044	uM	-	—	CRBN	CRBN	-	PGDB_A010814	PGDB_C000393	PGDB_AS001482	View
EC50	-	=	0.026	uM	-	—	CRBN	CRBN	-	PGDB_A010955	PGDB_C000416	PGDB_AS001482	View

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