PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberWO2022219412A1

AssigneeMonte Rosa Therapeutics

TitleIsoindolinone amide compounds useful to treat diseases associated with gspt1

Family ID81975178

Family members3

Filing year2022

Publication date2022-10-20

JurisdictionWO

Compounds52

Activity records92

Assays9

Activity compounds and values

Activity records

92 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
DC50	-	=	27	nM	-	—	-	-	MM.1S	PGDB_A009421	PGDB_C001760	PGDB_AS001567	View
DC50	-	=	22	nM	-	—	-	-	MM.1S	PGDB_A009589	PGDB_C001763	PGDB_AS001567	View
IC50	-	>	1100	nM	-	—	CRBN	CRBN	-	PGDB_A009813	PGDB_C011110	PGDB_AS000438	View
IC50	-	>	1100	nM	-	—	CRBN	CRBN	-	PGDB_A010592	PGDB_C001751	PGDB_AS002571	View
IC50	-	>	1100	nM	-	—	CRBN	CRBN	-	PGDB_A010868	PGDB_C001759	PGDB_AS002571	View
IC50	-	>	500	nM	-	—	CRBN	CRBN	-	PGDB_A011223	PGDB_C001726	PGDB_AS002571	View
IC50	-	>	500	nM	-	—	CRBN	CRBN	-	PGDB_A011643	PGDB_C001773	PGDB_AS002571	View
IC50	-	>	1100	nM	-	—	CRBN	CRBN	-	PGDB_A011743	PGDB_C001754	PGDB_AS002571	View
IC50	-	>	500	nM	-	—	CRBN	CRBN	-	PGDB_A012299	PGDB_C001746	PGDB_AS001297	View
DC50	-	=	17	nM	-	—	-	-	MM.1S	PGDB_A014499	PGDB_C001779	PGDB_AS001567	View
IC50	-	>	1700	nM	-	—	CRBN	CRBN	-	PGDB_A015011	PGDB_C001738	PGDB_AS001297	View
IC50	-	<=	500	nM	-	—	CRBN	CRBN	-	PGDB_A015055	PGDB_C001724	PGDB_AS000438	View
IC50	-	>	500	nM	-	—	CRBN	CRBN	-	PGDB_A015604	PGDB_C001728	PGDB_AS001297	View
IC50	-	>	500	nM	-	—	CRBN	CRBN	-	PGDB_A016237	PGDB_C001765	PGDB_AS002571	View
IC50	-	<=	500	nM	-	—	CRBN	CRBN	-	PGDB_A017011	PGDB_C001724	PGDB_AS002571	View
IC50	-	>	500	nM	-	—	CRBN	CRBN	-	PGDB_A017567	PGDB_C001729	PGDB_AS002571	View
IC50	-	>	500	nM	-	—	CRBN	CRBN	-	PGDB_A017714	PGDB_C001740	PGDB_AS002571	View
IC50	-	>	500	nM	-	—	CRBN	CRBN	-	PGDB_A019208	PGDB_C000482	PGDB_AS002571	View
IC50	-	>	500	nM	-	—	CRBN	CRBN	-	PGDB_A020270	PGDB_C001736	PGDB_AS001297	View
IC50	-	>	1100	nM	-	—	CRBN	CRBN	-	PGDB_A021271	PGDB_C001756	PGDB_AS002571	View

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