PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberWO2026041143A1

AssigneeWuhan Humanwell Innovative Drug Research And Development Center

TitleDiketone biphenyl compound as vav1 degradation agent, and use thereof

Family ID98864551

Family members2

Filing year2025

Publication date2026-02-26

JurisdictionWO

Compounds4

Activity records8

Assays2

Activity compounds and values

Activity records

8 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
Dmax	-	=	98.1	%	Concentration series: 1000 nM, 250 nM, 62.5 nM, 15.6 nM, 3.9 nM, 0.98 nM, 0.24 nM, 0 nM	24 h	VAV1	-	Jurkat	PGDB_A014016	PGDB_C009245	PGDB_AS000206	View
DC50	-	<=	10	nM	-	—	VAV1	-	Jurkat	PGDB_A039440	PGDB_C009245	PGDB_AS001882	View
Dmax	-	=	97	%	Concentration series: 1000 nM, 250 nM, 62.5 nM, 15.6 nM, 3.9 nM, 0.98 nM, 0.24 nM, 0 nM	24 h	VAV1	-	Jurkat	PGDB_A040912	PGDB_C009246	PGDB_AS000206	View
DC50	-	<=	10	nM	-	—	VAV1	-	Jurkat	PGDB_A041053	PGDB_C009248	PGDB_AS001882	View
Dmax	-	=	96	%	Concentration series: 1000 nM, 250 nM, 62.5 nM, 15.6 nM, 3.9 nM, 0.98 nM, 0.24 nM, 0 nM	24 h	VAV1	-	Jurkat	PGDB_A053339	PGDB_C009248	PGDB_AS000206	View
Dmax	-	=	97.7	%	Concentration series: 1000 nM, 250 nM, 62.5 nM, 15.6 nM, 3.9 nM, 0.98 nM, 0.24 nM, 0 nM	24 h	VAV1	-	Jurkat	PGDB_A056571	PGDB_C009247	PGDB_AS000206	View
DC50	-	<=	10	nM	-	—	VAV1	-	Jurkat	PGDB_A061325	PGDB_C009246	PGDB_AS001882	View
DC50	-	<=	10	nM	-	—	VAV1	-	Jurkat	PGDB_A077287	PGDB_C009247	PGDB_AS001882	View

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