PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberWO2026098637A1

AssigneeJiangsu Hengrui Pharmaceuticals Co Ltd, Shanghai Hengrui Pharmaceutical

TitleTRICYCLIC COMPOUND, AND PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF

Family IDunresolved_family_WO2026098637A1

Family members1

Filing year2025

Publication date2026-05-15

JurisdictionWO

Compounds6

Activity records16

Assays6

Activity compounds and values

Activity records

16 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
Dmax	-	=	98.8	%	-	24 h	VAV1	-	Jurkat	PGDB_A001767	PGDB_C031193	PGDB_AS001360	View
DC50	-	=	2.5	nM	-	—	VAV1	-	Jurkat	PGDB_A002169	PGDB_C031196	PGDB_AS000531	View
Dmax	-	=	98.9	%	-	24 h	VAV1	-	Jurkat	PGDB_A002233	PGDB_C031198	PGDB_AS001360	View
DC50	-	=	3.3	nM	-	—	VAV1	-	Jurkat	PGDB_A002262	PGDB_C031197	PGDB_AS000531	View
Dmax	-	=	98.7	%	-	24 h	VAV1	-	Jurkat	PGDB_A002835	PGDB_C031197	PGDB_AS001360	View
DC50	-	=	4.1	nM	-	—	VAV1	-	Jurkat	PGDB_A003366	PGDB_C031193	PGDB_AS000531	View
DC50	-	=	2.9	nM	-	—	VAV1	-	Jurkat	PGDB_A003755	PGDB_C031199	PGDB_AS000531	View
DC50	-	=	0.4	nM	-	—	VAV1	-	-	PGDB_A004843	PGDB_C031198	PGDB_AS001476	View
DC50	-	=	3.1	nM	-	—	VAV1	-	Jurkat	PGDB_A005964	PGDB_C031195	PGDB_AS000531	View
Dmax	-	=	98.9	%	-	24 h	VAV1	-	Jurkat	PGDB_A006064	PGDB_C031199	PGDB_AS001360	View
Dmax	-	=	99.5	%	-	24 h	VAV1	-	Jurkat	PGDB_A006771	PGDB_C031196	PGDB_AS001360	View
Dmax	-	=	98.2	%	-	24 h	VAV1	-	Jurkat	PGDB_A077902	PGDB_C031195	PGDB_AS001360	View
DC50	-	=	2.8	nM	-	—	VAV1	-	Jurkat	PGDB_A078170	PGDB_C031198	PGDB_AS000531	View
Dmax	-	=	96.5	%	-	24 h	VAV1	-	-	PGDB_A078779	PGDB_C031198	PGDB_AS002175	View
DC50	-	=	36.6	nM	-	—	VAV1	-	-	PGDB_A078948	PGDB_C031198	PGDB_AS001571	View
Dmax	-	=	99.2	%	-	24 h	VAV1	-	-	PGDB_A079426	PGDB_C031198	PGDB_AS002286	View

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