PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberWO2026128580A1

AssigneeNurix Therapeutics Inc

TitleBIFUNCTIONAL SELECTIVE DEGRADERS OF SMARCA2 AND THERAPEUTIC USES THEREOF

Family IDunresolved_family_WO2026128580A1

Family members1

Filing year2025

Publication date2026-06-18

JurisdictionWO

Compounds174

Activity records716

Assays4

Activity compounds and values

Activity records

716 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
DC50	-	=	10000	nM	-	—	SMARCA4	-	Calu-6	PGDB_A000005	PGDB_C032272	PGDB_AS001413	View
DC50	-	=	10000	nM	-	—	SMARCA4	-	Calu-6	PGDB_A000008	PGDB_C032265	PGDB_AS001413	View
Dmax	-	=	82.64	%	-	-	SMARCA2	-	Calu-6	PGDB_A000031	PGDB_C032405	PGDB_AS002073	View
DC50	-	=	43.4	nM	-	—	SMARCA4	-	Calu-6	PGDB_A000050	PGDB_C032365	PGDB_AS001413	View
Dmax	-	=	84.53	%	-	-	SMARCA2	-	Calu-6	PGDB_A000053	PGDB_C032432	PGDB_AS002073	View
Dmax	-	=	88.35	%	-	-	SMARCA2	-	Calu-6	PGDB_A000057	PGDB_C032399	PGDB_AS002073	View
Dmax	-	=	90.47	%	-	-	SMARCA2	-	Calu-6	PGDB_A000069	PGDB_C032311	PGDB_AS002073	View
Dmax	-	=	40.77	%	-	5 min	SMARCA4	-	Calu-6	PGDB_A000110	PGDB_C032359	PGDB_AS002111	View
DC50	-	=	1000	nM	-	—	SMARCA4	-	Calu-6	PGDB_A000113	PGDB_C032341	PGDB_AS001413	View
Dmax	-	=	33.51	%	-	5 min	SMARCA4	-	Calu-6	PGDB_A000114	PGDB_C032361	PGDB_AS002111	View
DC50	-	=	1000	nM	-	—	SMARCA4	-	Calu-6	PGDB_A000157	PGDB_C032404	PGDB_AS001413	View
DC50	-	=	4.88	nM	-	—	SMARCA2	-	Calu-6	PGDB_A000162	PGDB_C032383	PGDB_AS002506	View
Dmax	-	=	97.57	%	-	-	SMARCA2	-	Calu-6	PGDB_A000171	PGDB_C032416	PGDB_AS002073	View
Dmax	-	=	24.33	%	-	5 min	SMARCA4	-	Calu-6	PGDB_A000172	PGDB_C032394	PGDB_AS002111	View
Dmax	-	=	49.51	%	-	5 min	SMARCA4	-	Calu-6	PGDB_A000196	PGDB_C032398	PGDB_AS002111	View
Dmax	-	=	56.27	%	-	5 min	SMARCA4	-	Calu-6	PGDB_A000204	PGDB_C032376	PGDB_AS002111	View
DC50	-	=	10000	nM	-	—	SMARCA4	-	Calu-6	PGDB_A000238	PGDB_C032441	PGDB_AS001413	View
DC50	-	=	41.7	nM	-	—	SMARCA4	-	Calu-6	PGDB_A000240	PGDB_C032325	PGDB_AS001413	View
DC50	-	=	0.9	nM	-	—	SMARCA2	-	Calu-6	PGDB_A000241	PGDB_C032416	PGDB_AS002506	View
DC50	-	=	1000	nM	-	—	SMARCA4	-	Calu-6	PGDB_A000258	PGDB_C032357	PGDB_AS001413	View

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