Assay

PGDB_AS000920

System: cell_basedTarget: CSNK1A1Cell line: HT-1080
Assay context summary

Assay context

90 activity records
Assay family% Degradation
Systemcell_based
ReadoutDmax
TargetCSNK1A1
E3CRBN
Cell lineHT-1080
OrganismHomo sapiens
Detection targetprotein_degradation
Activity compounds and values

Activity records

90 records
StructureMetricControlRelationValueUnitConcentrationTimeTargetE3Cell linePatentRecord IDCompoundAssayDetails
2D structure for PGDB_C001801
Dmax-=68.1%10 uM20 hCSNK1A1CRBNHT-1080WO2022257897A1PGDB_A007894PGDB_C001801PGDB_AS000920View
2D structure for PGDB_C001794
Dmax-=60.8%10 uM20 hCSNK1A1CRBNHT-1080WO2022257897A1PGDB_A008412PGDB_C001794PGDB_AS000920View
2D structure for PGDB_C001842
Dmax-=66%10 uM20 hCSNK1A1CRBNHT-1080WO2022257897A1PGDB_A008471PGDB_C001842PGDB_AS000920View
2D structure for PGDB_C001835
Dmax-=64.1%10 uM20 hCSNK1A1CRBNHT-1080WO2022257897A1PGDB_A009193PGDB_C001835PGDB_AS000920View
2D structure for PGDB_C001810
Dmax-=49.5%10 uM20 hCSNK1A1CRBNHT-1080WO2022257897A1PGDB_A011960PGDB_C001810PGDB_AS000920View
2D structure for PGDB_C001815
Dmax-=70.2%10 uM20 hCSNK1A1CRBNHT-1080WO2022257897A1PGDB_A012948PGDB_C001815PGDB_AS000920View
2D structure for PGDB_C001854
Dmax-=65.5%10 uM20 hCSNK1A1CRBNHT-1080WO2022257897A1PGDB_A013381PGDB_C001854PGDB_AS000920View
2D structure for PGDB_C001815
Dmax-=62.3%10 uM20 hCSNK1A1CRBNHT-1080WO2022257897A1PGDB_A015743PGDB_C001815PGDB_AS000920View
2D structure for PGDB_C001851
Dmax-=74%10 uM20 hCSNK1A1CRBNHT-1080WO2022257897A1PGDB_A017286PGDB_C001851PGDB_AS000920View
2D structure for PGDB_C001805
Dmax-=61%10 uM20 hCSNK1A1CRBNHT-1080WO2022257897A1PGDB_A017323PGDB_C001805PGDB_AS000920View
2D structure for PGDB_C001829
Dmax-=48.1%10 uM20 hCSNK1A1CRBNHT-1080WO2022257897A1PGDB_A018646PGDB_C001829PGDB_AS000920View
2D structure for PGDB_C001850
Dmax-=55.4%10 uM20 hCSNK1A1CRBNHT-1080WO2022257897A1PGDB_A019988PGDB_C001850PGDB_AS000920View
2D structure for PGDB_C001816
Dmax-=63.6%10 uM20 hCSNK1A1CRBNHT-1080WO2022257897A1PGDB_A020997PGDB_C001816PGDB_AS000920View
2D structure for PGDB_C001802
Dmax-=66%10 uM20 hCSNK1A1CRBNHT-1080WO2022257897A1PGDB_A021106PGDB_C001802PGDB_AS000920View
2D structure for PGDB_C001785
Dmax-=63.4%10 uM20 hCSNK1A1CRBNHT-1080WO2022257897A1PGDB_A021300PGDB_C001785PGDB_AS000920View
2D structure for PGDB_C001803
Dmax-=69.6%10 uM20 hCSNK1A1CRBNHT-1080WO2022257897A1PGDB_A021361PGDB_C001803PGDB_AS000920View
2D structure for PGDB_C001813
Dmax-=68.6%10 uM20 hCSNK1A1CRBNHT-1080WO2022257897A1PGDB_A021757PGDB_C001813PGDB_AS000920View
2D structure for PGDB_C001823
Dmax-=54.5%10 uM20 hCSNK1A1CRBNHT-1080WO2022257897A1PGDB_A022520PGDB_C001823PGDB_AS000920View
2D structure for PGDB_C001844
Dmax-=49%10 uM20 hCSNK1A1CRBNHT-1080WO2022257897A1PGDB_A022788PGDB_C001844PGDB_AS000920View
2D structure for PGDB_C001836
Dmax-=41.1%10 uM20 hCSNK1A1CRBNHT-1080WO2022257897A1PGDB_A023106PGDB_C001836PGDB_AS000920View
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