PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3c(C(=O)N4CCC(N5CCN(c6noc7cc(F)ccc67)CC5)CC4)cccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C000922

FormulaC30H31FN6O5

Molecular weight574.613

InChIKeyGCHHSGLHHCAOPB-UHFFFAOYSA-N

Physicochemical properties

Exact mass574.234

RDKit cLogP2.15

TPSA119.3

HBD / HBA1 / 8

Rotatable bonds4

Heavy atoms42

Hetero atoms12

Rings / aromatic7 / 3

Fraction Csp30.43

Formal charge0

Fragments1

Activity compounds and values

Activity records

10 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Inhibition	-	=	40-50	%	500 nM	-	-	-	MOLT-4	CN120548310A	PGDB_A009667	PGDB_C000922	PGDB_AS000553	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	CN120548310A	PGDB_A013853	PGDB_C000922	PGDB_AS000946	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	CN120548310A	PGDB_A021263	PGDB_C000922	PGDB_AS001466	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	CN120548310A	PGDB_A030973	PGDB_C000922	PGDB_AS000102	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	CN120548310A	PGDB_A031830	PGDB_C000922	PGDB_AS002025	View
% Inhibition	-	=	20-30	%	0.5 uM	-	CRBN	CRBN	-	CN120548310A	PGDB_A031934	PGDB_C000922	PGDB_AS002000	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	CN120548310A	PGDB_A035319	PGDB_C000922	PGDB_AS001655	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	CN120548310A	PGDB_A041858	PGDB_C000922	PGDB_AS001449	View
% Inhibition	-	=	30-40	%	10 nM	-	-	-	MOLT-4	CN120548310A	PGDB_A061754	PGDB_C000922	PGDB_AS001814	View
% Inhibition	-	=	53-60	%	2 uM	-	CRBN	CRBN	-	CN120548310A	PGDB_A062273	PGDB_C000922	PGDB_AS001462	View

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