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Compound
PGDB_C002495
8 activity records1 related patents
2D structure
CC1(C)CCC(CN2CCN(Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(F)cc2)C1Compound summary
Physicochemical properties
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IC50 | - | = | 1000-5000 | nM | - | — | - | - | Ramos | WO2024032689A1 | PGDB_A011263 | PGDB_C002495 | PGDB_AS002308 | View |
| IC50 | - | = | 100-500 | nM | - | — | - | - | MM.1R | WO2024032689A1 | PGDB_A019885 | PGDB_C002495 | PGDB_AS000212 | View |
| IC50 | - | = | 0.41 | uM | - | — | CRBN | CRBN | - | WO2024032689A1 | PGDB_A020875 | PGDB_C002495 | PGDB_AS000095 | View |
| % Degradation | - | > | 50 | % | Concentration context: 500 nM | 24 h | IKZF3 | - | - | WO2024032689A1 | PGDB_A021050 | PGDB_C002495 | PGDB_AS000176 | View |
| IC50 | - | = | 1000-5000 | nM | - | — | - | - | TMD8 | WO2024032689A1 | PGDB_A025731 | PGDB_C002495 | PGDB_AS001559 | View |
| % Degradation | - | > | 50 | % | Concentration context: 500 nM | 24 h | IKZF1 | - | - | WO2024032689A1 | PGDB_A071101 | PGDB_C002495 | PGDB_AS002239 | View |
| % Degradation | - | > | 50 | % | Concentration context: 500 nM | 24 h | GSPT1 | - | - | WO2024032689A1 | PGDB_A072314 | PGDB_C002495 | PGDB_AS000668 | View |
| IC50 | - | = | 10-50 | nM | - | — | - | - | CCRF-CEM | WO2024032689A1 | PGDB_A074567 | PGDB_C002495 | PGDB_AS001396 | View |