PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberWO2024032689A1

AssigneeGluetacs Therapeutics Shanghai

TitleCompounds based on isoindoline-substituted glutarimide skeleton and their applications

Family ID89850926

Family members7

Filing year2023

Publication date2024-04-12

JurisdictionWO

Compounds300

Activity records939

Assays17

Activity compounds and values

Activity records

939 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
IC50	-	=	1.57	uM	-	—	CRBN	CRBN	-	PGDB_A007049	PGDB_C002686	PGDB_AS000095	View
IC50	-	=	1.41	uM	-	—	CRBN	CRBN	-	PGDB_A007148	PGDB_C002765	PGDB_AS000095	View
IC50	-	=	100-500	nM	-	—	-	-	CCRF-CEM	PGDB_A007318	PGDB_C002507	PGDB_AS001396	View
IC50	-	=	0.31	uM	-	—	CRBN	CRBN	-	PGDB_A007336	PGDB_C002529	PGDB_AS000095	View
IC50	-	=	0.2	uM	-	—	CRBN	CRBN	-	PGDB_A007387	PGDB_C002737	PGDB_AS000095	View
IC50	-	=	100-500	nM	-	—	-	-	MM.1S	PGDB_A007506	PGDB_C002540	PGDB_AS001703	View
IC50	-	<=	5	nM	-	—	-	-	CCRF-CEM	PGDB_A007682	PGDB_C002501	PGDB_AS001396	View
IC50	-	=	1.2	uM	-	—	CRBN	CRBN	-	PGDB_A007699	PGDB_C002712	PGDB_AS000095	View
% Degradation	-	>	50	%	Concentration context: 500 nM	24 h	IKZF1	-	-	PGDB_A007712	PGDB_C002556	PGDB_AS002239	View
% Degradation	-	>	50	%	Concentration context: 500 nM	24 h	IKZF1	-	-	PGDB_A007764	PGDB_C002563	PGDB_AS002239	View
% Degradation	-	>	50	%	Concentration context: 500 nM	24 h	IKZF3	-	-	PGDB_A007888	PGDB_C002534	PGDB_AS000176	View
IC50	-	=	0.94	uM	-	—	CRBN	CRBN	-	PGDB_A007902	PGDB_C002739	PGDB_AS000095	View
IC50	-	=	5-10	nM	-	—	-	-	CCRF-CEM	PGDB_A007916	PGDB_C002560	PGDB_AS001396	View
IC50	-	=	500-1000	nM	-	—	-	-	CCRF-CEM	PGDB_A007997	PGDB_C002510	PGDB_AS001396	View
% Degradation	-	<	50	%	Concentration context: 500 nM	24 h	IKZF1	-	-	PGDB_A008041	PGDB_C002601	PGDB_AS002239	View
IC50	-	=	1.1	uM	-	—	CRBN	CRBN	-	PGDB_A008319	PGDB_C002725	PGDB_AS000095	View
IC50	-	=	10-50	nM	-	—	-	-	Mino	PGDB_A008349	PGDB_C002516	PGDB_AS001319	View
IC50	-	=	10-50	nM	-	—	-	-	Kasumi-1	PGDB_A008367	PGDB_C002488	PGDB_AS001291	View
% Degradation	-	>	50	%	Concentration context: 500 nM	24 h	IKZF3	-	-	PGDB_A008508	PGDB_C002592	PGDB_AS000176	View
IC50	-	=	2.5	nM	-	—	-	-	CCRF-CEM	PGDB_A008651	PGDB_C002534	PGDB_AS001396	View

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