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Compound
PGDB_C002563
8 activity records1 related patents
2D structure
O=C1CCC(N2Cc3cc(CN4CCN(Cc5ncccc5-c5ccc(Cl)cc5)CC4)ccc3C2=O)C(=O)N1Compound summary
Physicochemical properties
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| % Degradation | - | > | 50 | % | Concentration context: 500 nM | 24 h | IKZF1 | - | - | WO2024032689A1 | PGDB_A007764 | PGDB_C002563 | PGDB_AS002239 | View |
| IC50 | - | <= | 5 | nM | - | — | - | - | CCRF-CEM | WO2024032689A1 | PGDB_A009871 | PGDB_C002563 | PGDB_AS001396 | View |
| IC50 | - | = | 5-10 | nM | - | — | - | - | Daudi | WO2024032689A1 | PGDB_A010354 | PGDB_C002563 | PGDB_AS002481 | View |
| % Degradation | - | > | 50 | % | Concentration context: 500 nM | 24 h | GSPT1 | - | - | WO2024032689A1 | PGDB_A021980 | PGDB_C002563 | PGDB_AS000668 | View |
| IC50 | - | <= | 5 | nM | - | — | - | - | Mino | WO2024032689A1 | PGDB_A027924 | PGDB_C002563 | PGDB_AS001319 | View |
| % Degradation | - | > | 50 | % | Concentration context: 500 nM | 24 h | IKZF3 | - | - | WO2024032689A1 | PGDB_A042280 | PGDB_C002563 | PGDB_AS000176 | View |
| IC50 | - | = | 0.56 | uM | - | — | CRBN | CRBN | - | WO2024032689A1 | PGDB_A074920 | PGDB_C002563 | PGDB_AS000095 | View |
| IC50 | - | <= | 5 | nM | - | — | - | - | MM.1S | WO2024032689A1 | PGDB_A077421 | PGDB_C002563 | PGDB_AS001703 | View |