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Compound
PGDB_C006606
5 activity records1 related patents
2D structure
Cc1cc(C(F)(F)F)cc2nc(CNc3cc(NC[C@H]4CCNC[C@@H]4O)nc4c(C5CC5)cnn34)cn12Compound summary
Physicochemical properties
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Selectivity index | CDK7 / CDK12 | = | 38.1 | fold | - | — | - | - | - | CN114929708B | PGDB_A012206 | PGDB_C006606 | PGDB_AS002236 | View |
| IC50 | - | = | 48 | nM | - | — | CDK12 | - | - | CN114929708B | PGDB_A013039 | PGDB_C006606 | PGDB_AS001268 | View |
| IC50 | - | = | 48 | nM | - | — | CDK12 | - | - | CN114929708B | PGDB_A039246 | PGDB_C006606 | PGDB_AS001187 | View |
| IC50 | - | = | 4 | nM | - | — | CDK12 | - | A673 | CN114929708B | PGDB_A059335 | PGDB_C006606 | PGDB_AS002570 | View |
| IC50 | - | = | 1830 | nM | - | — | CDK7 | - | - | CN114929708B | PGDB_A072988 | PGDB_C006606 | PGDB_AS002150 | View |