PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberCN114929708B

AssigneeCarrick Treatment

Title4-[[(7-aminopyrazolo[1,5-a]pyrimidin-5-yl)amino]methyl]piperidin-3-ol compounds and their therapeutic uses

Family ID69186648

Family members12

Filing year2020

Publication date2025-02-18

JurisdictionCN

Compounds48

Activity records244

Assays7

Activity compounds and values

Activity records

244 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
IC50	-	=	18	nM	-	—	CDK12	-	-	PGDB_A007206	PGDB_C006612	PGDB_AS001268	View
IC50	-	=	37	nM	-	—	CDK12	-	-	PGDB_A007534	PGDB_C006595	PGDB_AS001268	View
IC50	-	=	253	nM	-	—	CDK12	-	-	PGDB_A008142	PGDB_C006566	PGDB_AS001187	View
IC50	-	=	100	nM	-	—	CDK12	-	-	PGDB_A008731	PGDB_C006609	PGDB_AS001268	View
IC50	-	=	1.6	nM	-	—	CDK12	-	A673	PGDB_A008825	PGDB_C006594	PGDB_AS002570	View
IC50	-	=	1060	nM	-	—	CDK7	-	-	PGDB_A009300	PGDB_C006600	PGDB_AS002150	View
Selectivity index	CDK7 / CDK12	=	5.9	fold	-	—	-	-	-	PGDB_A009464	PGDB_C006571	PGDB_AS002236	View
Selectivity index	CDK7 / CDK12	=	3.1	fold	-	—	-	-	-	PGDB_A009806	PGDB_C006604	PGDB_AS002236	View
IC50	-	=	46	nM	-	—	CDK12	-	-	PGDB_A010565	PGDB_C006608	PGDB_AS001187	View
IC50	-	=	55	nM	-	—	CDK12	-	-	PGDB_A010600	PGDB_C006571	PGDB_AS001066	View
IC50	-	=	46	nM	-	—	CDK12	-	-	PGDB_A010708	PGDB_C006608	PGDB_AS001268	View
IC50	-	=	38	nM	-	—	CDK12	-	-	PGDB_A011096	PGDB_C006576	PGDB_AS001268	View
IC50	-	=	597	nM	-	—	CDK12	-	-	PGDB_A011106	PGDB_C006567	PGDB_AS001187	View
IC50	-	=	18.1	nM	-	—	CDK12	-	A673	PGDB_A011383	PGDB_C006604	PGDB_AS002570	View
IC50	-	=	65	nM	-	—	CDK12	-	-	PGDB_A011587	PGDB_C006596	PGDB_AS001187	View
IC50	-	=	27	nM	-	—	CDK12	-	A673	PGDB_A012187	PGDB_C006574	PGDB_AS002570	View
Selectivity index	CDK7 / CDK12	=	38.1	fold	-	—	-	-	-	PGDB_A012206	PGDB_C006606	PGDB_AS002236	View
IC50	-	=	48	nM	-	—	CDK12	-	-	PGDB_A012216	PGDB_C006607	PGDB_AS001187	View
IC50	-	=	50	nM	-	—	CDK12	-	-	PGDB_A012281	PGDB_C006570	PGDB_AS001268	View
IC50	-	=	110	nM	-	—	CDK12	-	A673	PGDB_A012469	PGDB_C006612	PGDB_AS002202	View

Rows per pagePage 1 of 13 · 244 recordsGo to page