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Compound
PGDB_C006607
5 activity records1 related patents
2D structure
Cc1cn2cc(CNc3cc(NC[C@H]4CCNC[C@@H]4O)nc4c(C5CC5)cnn34)nc2cc1C(F)(F)FCompound summary
Physicochemical properties
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IC50 | - | = | 48 | nM | - | — | CDK12 | - | - | CN114929708B | PGDB_A012216 | PGDB_C006607 | PGDB_AS001187 | View |
| IC50 | - | = | 48 | nM | - | — | CDK12 | - | - | CN114929708B | PGDB_A020921 | PGDB_C006607 | PGDB_AS001268 | View |
| Selectivity index | CDK7 / CDK12 | = | 31.9 | fold | - | — | - | - | - | CN114929708B | PGDB_A051389 | PGDB_C006607 | PGDB_AS002236 | View |
| IC50 | - | = | 1530 | nM | - | — | CDK7 | - | - | CN114929708B | PGDB_A055185 | PGDB_C006607 | PGDB_AS002150 | View |
| IC50 | - | = | 5.4 | nM | - | — | CDK12 | - | A673 | CN114929708B | PGDB_A062908 | PGDB_C006607 | PGDB_AS002570 | View |